Grant P A
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Jefferson Park Avenue, Charlottesville, VA 22908, USA.
Genome Biol. 2001;2(4):REVIEWS0003. doi: 10.1186/gb-2001-2-4-reviews0003. Epub 2001 Apr 5.
The modification of chromatin structure is important for a number of nuclear functions, exemplified by the regulation of transcription. This review discusses recent studies of covalent histone modifications and the enzymatic machines that generate them.
染色质结构的修饰对于许多核功能至关重要,转录调控就是一个例证。本综述讨论了共价组蛋白修饰以及产生这些修饰的酶机制的最新研究。