Graham E M, Freedman L J, Forouzan I
Department of Obstetrics and Gynecology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19131-1696, USA.
J Reprod Med. 1998 May;43(5):451-4.
Primary maternal hyperparathyroidism leads to increased serum calcium levels, which suppress fetal parathyroid development, leading to hypocalcemia in the neonate.
In a pregnant woman, hypercalcemia was observed to be related to a parathyroid adenoma that was surgically removed at 15 weeks' gestation. Subsequently, hypocalcemia developed, requiring calcium replacement. There was marked premature calcification of the placenta, noted to be grade 3 at 23 weeks, and this was thought to be related to the severe intrauterine growth retardation that later developed. Preterm premature rupture of membranes occurred at 33 weeks, and a growth-retarded neonate with a small, calcified placenta was delivered.
Pregnancies associated with hyperparathyroidism have been found to be complicated by an increased incidence of spontaneous abortion, stillbirth and neonatal tetany. There may also be an increased risk of fetal intrauterine growth retardation. Serial ultrasonography to evaluate fetal growth and antenatal testing should be considered.
原发性孕妇甲状旁腺功能亢进导致血清钙水平升高，这会抑制胎儿甲状旁腺发育，进而导致新生儿低钙血症。
在一名孕妇中，观察到高钙血症与甲状旁腺腺瘤有关，该腺瘤在妊娠15周时通过手术切除。随后出现了低钙血症，需要补充钙剂。胎盘出现明显的过早钙化，在孕23周时被判定为3级，这被认为与后来出现的严重宫内生长受限有关。孕33周时发生胎膜早破，分娩出一名生长受限的新生儿，其胎盘小且有钙化。
已发现与甲状旁腺功能亢进相关的妊娠会因自然流产、死产和新生儿手足搐搦的发生率增加而复杂化。胎儿宫内生长受限的风险也可能增加。应考虑通过超声检查评估胎儿生长情况并进行产前检查。
