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[碳水化合物消化与吸收的当前概念]

[Current concepts of digestion and absorption of carbohydrates].

作者信息

Luz S dos S, de Campos P L, Ribeiro S M, Tirapegui J

机构信息

Depto. de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas, São Paulo.

出版信息

Arq Gastroenterol. 1997 Jul-Sep;34(3):175-85.

PMID:9611296
Abstract

The aim of this paper is to review recent aspects of digestion and absorption of carbohydrates that are the main source of energy in human diets. Recent researches have found that starch is not largely hydrolysed and absorbed in the small bowel but one part of it is resistant to digestion. Several food factors may be responsible for digestion and absorption velocity and totality of carbohydrates. Therefore, carbohydrate classification must be based not only on molecular size to express the real carbohydrates utilization as an energy source by humans. In agreement with molecular size of carbohydrate, its classification can be: a) monosaccharides; b) disaccharides; c) oligosaccharides; d) polysaccharides. In agreement with carbohydrate digestibility or availability, its classification can be: a) digestible carbohydrates; b) undigestable carbohydrates (NSP). Carbohydrate digestibility can be altered by several factors like: Intrinsic factors: a) physical structure; b) molecular physical distribution; c) physical state of food; d) food antinutrients. Extrinsics factors: a) chewing; b) transit time of food; c) amount of starch present; d) diet antinutrients. Under influence of this factors, process of digestion happen by enzymatic activity a long the gastrointestinal tract. Salivary and pancreatic amylase; glycosidases of the duodenal enterocyte brush border (lactase, sacarase and maltase), whose activity happen by close interaction of digestive breakdown with transport. The summarized pathways of the absorptive process: 1. movement from the bulk phase of the lumenal or mucosal fluid to enterocyte surface; 2. movement across the brush border membrane through specific transporters: a) SGLT1; b) GLUT 5; c) passive diffusion. 3. movement across the basolateral membrane by the GLUT 2.

摘要

本文旨在综述碳水化合物消化与吸收的最新研究进展,碳水化合物是人类饮食中的主要能量来源。最近的研究发现,淀粉在小肠中并非大量被水解和吸收,其中一部分对消化具有抗性。多种食物因素可能影响碳水化合物的消化吸收速度及总量。因此,碳水化合物的分类不仅应基于分子大小,以反映人类将其作为能量来源的实际利用情况。根据碳水化合物的分子大小,其分类可为:a)单糖;b)双糖;c)寡糖;d)多糖。根据碳水化合物的消化率或可利用性,其分类可为:a)可消化碳水化合物;b)不可消化碳水化合物(非淀粉多糖)。碳水化合物的消化率可受多种因素影响,如:内在因素:a)物理结构;b)分子物理分布;c)食物的物理状态;d)食物抗营养因子。外在因素:a)咀嚼;b)食物通过时间;c)淀粉含量;d)膳食抗营养因子。在这些因素的影响下,消化过程通过胃肠道中的酶活性进行。唾液淀粉酶和胰淀粉酶;十二指肠肠细胞刷状缘的糖苷酶(乳糖酶、蔗糖酶和麦芽糖酶),其活性通过消化分解与转运的紧密相互作用而发生。吸收过程的总结途径:1. 从管腔或粘膜液的 bulk 相移动到肠细胞表面;2. 通过特定转运体穿过刷状缘膜:a)SGLT1;b)GLUT 5;c)被动扩散。3. 通过 GLUT 2 穿过基底外侧膜。

需注意,原文中“bulk phase”可能表述有误,准确说法或许是“bulk solution”( bulk 溶液),这里按照原文进行了翻译。

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