Saito N, Kuginuki T, Yagyu T, Kinoshita T, Koenig T, Pascual-Marqui R D, Kochi K, Wackermann J, Lehmann D
KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Zurick, Switzerland.
Biol Psychiatry. 1998 Jun 1;43(11):794-802. doi: 10.1016/s0006-3223(97)00547-7.
Schizophrenic symptoms commonly are felt to indicate a loosened coordination, i.e. a decreased connectivity of brain processes.
To address this hypothesis directly, global and regional multichannel electroencephalographic (EEG) complexities (omega complexity and dimensional complexity) and single channel EEG dimensional complexities were calculated from 19-channel EEG data from 9 neuroleptic-naive, first-break, acute schizophrenics and 9 age- and sex-matched controls. Twenty artifact-free 2 second EEG epochs during resting with closed eyes were analyzed (2-30 Hz bandpass, average reference for global and regional complexities, local EEG gradient time series for single channels).
Anterior regional Omega-Complexity was significantly increased in schizophrenics compared with controls (p < 0.001) and anterior regional Dimensional Complexity showed a trend for increase. Single channel Dimensional Complexity of local gradient waveshapes was prominently increased in the schizophrenics at the right precentral location (p = 0.003).
The results indicate a loosened cooperativity or coordination (vice versa: an increased independence) of the active brain processes in the anterior brain regions of the schizophrenics.
通常认为精神分裂症症状表明协调性减弱，即大脑过程的连接性降低。
为了直接验证这一假设，从9名未使用过抗精神病药物、首次发病、急性精神分裂症患者以及9名年龄和性别匹配的对照组的19导脑电图数据中计算了全局和区域多通道脑电图（EEG）复杂性（ω复杂性和维度复杂性）以及单通道EEG维度复杂性。分析了闭眼静息时20个无伪迹的2秒EEG片段（2 - 30Hz带通，全局和区域复杂性采用平均参考，单通道采用局部EEG梯度时间序列）。
与对照组相比，精神分裂症患者的前区ω复杂性显著增加（p < 0.001），前区维度复杂性有增加趋势。精神分裂症患者右侧中央前回位置的局部梯度波形单通道维度复杂性显著增加（p = 0.003）。
结果表明精神分裂症患者前脑区域活跃的大脑过程的协同性或协调性减弱（反之：独立性增加）。
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