• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Muscle maturation: implications for gene therapy.

作者信息

van Deutekom J C, Hoffman E P, Huard J

机构信息

Dept. of Orthopaedic Surgery, Children's Hospital of Pittsburgh, PA 15213, USA.

出版信息

Mol Med Today. 1998 May;4(5):214-20. doi: 10.1016/s1357-4310(98)01231-3.

DOI:10.1016/s1357-4310(98)01231-3
PMID:9612801
Abstract

Skeletal muscle is a promising target tissue for gene therapy, for both muscle and non-muscle disorders. A variety of methods have been studied to transfer genes into skeletal muscle, including retroviral, adenoviral and herpes simplex viral vectors. However, various factors impede muscle-based viral gene therapy. Here, we discuss why some viral vectors cannot efficiently transduce mature muscle fibers, and describe some new approaches to overcome this barrier.

摘要

相似文献

1
Muscle maturation: implications for gene therapy.
Mol Med Today. 1998 May;4(5):214-20. doi: 10.1016/s1357-4310(98)01231-3.
2
Systemic administration of naked DNA: gene transfer to skeletal muscle.裸DNA的全身给药：基因向骨骼肌的转移。
Mol Interv. 2001 Aug;1(3):168-72.
3
Gene therapy of Duchenne muscular dystrophy.杜氏肌营养不良症的基因治疗。
Adv Genet. 1997;35:117-53. doi: 10.1016/s0065-2660(08)60449-6.
4
Systemic gene transfer to skeletal muscle using reengineered AAV vectors.使用重新设计的腺相关病毒载体将基因全身性转移至骨骼肌。
Methods Mol Biol. 2011;709:141-51. doi: 10.1007/978-1-61737-982-6_9.
5
Herpes simplex virus VP22 enhances adenovirus-mediated microdystrophin gene transfer to skeletal muscles in dystrophin-deficient (mdx) mice.单纯疱疹病毒VP22增强腺病毒介导的微肌营养不良蛋白基因向肌营养不良蛋白缺陷（mdx）小鼠骨骼肌的转移。
Hum Gene Ther. 2007 Jun;18(6):490-501. doi: 10.1089/hum.2006.155.
6
Viral gene delivery to skeletal muscle: insights on maturation-dependent loss of fiber infectivity for adenovirus and herpes simplex type 1 viral vectors.
Hum Gene Ther. 1997 Mar 1;8(4):371-80. doi: 10.1089/hum.1997.8.4-371.
7
Extended tropism of an adenoviral vector does not circumvent the maturation-dependent transducibility of mouse skeletal muscle.
J Gene Med. 1999 Nov-Dec;1(6):393-9. doi: 10.1002/(SICI)1521-2254(199911/12)1:6<393::AID-JGM65>3.0.CO;2-U.
8
Gene transfer establishes primacy of striated vs. smooth muscle sarcoglycan complex in limb-girdle muscular dystrophy.基因转移确立了肢带型肌营养不良中横纹肌与平滑肌肌聚糖复合物的首要地位。
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8910-5. doi: 10.1073/pnas.1537554100. Epub 2003 Jul 8.
9
Myostatin propeptide gene delivery by adeno-associated virus serotype 8 vectors enhances muscle growth and ameliorates dystrophic phenotypes in mdx mice.通过8型腺相关病毒载体递送肌生成抑制蛋白前肽基因可增强mdx小鼠的肌肉生长并改善营养不良表型。
Hum Gene Ther. 2008 Mar;19(3):241-54. doi: 10.1089/hum.2007.159.
10
Retroviral-mediated gene transfer into murine and human skeletal muscle for the correction of dystrophin deficiency.
Biochem Soc Trans. 1996 May;24(2):275S. doi: 10.1042/bst024275s.

引用本文的文献

1
Gene delivery by surface immobilization of plasmid to tissue-engineering scaffolds.通过将质粒表面固定在组织工程支架上来进行基因传递。
Gene Ther. 2010 Sep;17(9):1134-41. doi: 10.1038/gt.2010.79. Epub 2010 May 20.
2
The role of cell type in bone healing mediated by ex vivo gene therapy.
Langenbecks Arch Surg. 2003 Oct;388(5):347-55. doi: 10.1007/s00423-003-0401-7. Epub 2003 Oct 8.
3
Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation.通过裸DNA注射和肌肉电穿孔实现高效且受调控的促红细胞生成素生产。
Proc Natl Acad Sci U S A. 1999 May 25;96(11):6417-22. doi: 10.1073/pnas.96.11.6417.
4
Development of approaches to improve cell survival in myoblast transfer therapy.提高成肌细胞移植治疗中细胞存活率方法的研究进展
J Cell Biol. 1998 Sep 7;142(5):1257-67. doi: 10.1083/jcb.142.5.1257.