Chabas E, Gomar C, Villalonga A, Sala X, Taura P
Department of Anaesthesia, Hospital Clinic, Barcelona, Spain.
Anaesthesia. 1998 Apr;53(4):393-7. doi: 10.1046/j.1365-2044.1998.00325.x.
Thirty children undergoing urological and abdominal surgery were entered into a randomised trial comparing the effects of epidural and intramuscular morphine on postoperative respiratory function. The forced vital capacity and the forced expired volume in 1 s were measured before and 6 h after surgery and on each of the following seven days. Significant decreases (p < 0.01) in forced vital capacity and forced expired volume in 1 s were seen after surgery. After the first postoperative day, a gradual recovery in pulmonary function was observed but the measured parameters had not returned to their pre-operative control values by the end of the study. There were no statistically significant differences between the two groups during the study with respect to forced vital capacity and forced expired volume in 1 s. The quality of analgesia was better in the epidural morphine group than in the intramuscular morphine group. The incomplete recovery of pulmonary function suggests that pain is not the only cause of postoperative respiratory changes in these patients.
30名接受泌尿外科和腹部手术的儿童参与了一项随机试验，比较硬膜外吗啡和肌肉注射吗啡对术后呼吸功能的影响。在手术前、术后6小时以及随后7天的每一天，测量用力肺活量和1秒用力呼气量。术后用力肺活量和1秒用力呼气量显著下降（p<0.01）。术后第一天后，观察到肺功能逐渐恢复，但到研究结束时，测量参数仍未恢复到术前对照值。在研究期间，两组在用力肺活量和1秒用力呼气量方面无统计学显著差异。硬膜外吗啡组的镇痛质量优于肌肉注射吗啡组。肺功能未完全恢复表明，疼痛并非这些患者术后呼吸变化的唯一原因。
