Jouppila R, Hollmén A
Acta Anaesthesiol Scand. 1976;20(3):259-68. doi: 10.1111/j.1399-6576.1976.tb05038.x.
Maternal and foetal acid-base balance, PaO2, lactate, potassium and creatine phosphokinase (CPK) were studied during the course of 28 induced labours. Every second mother received segmental epidural analgesia during the first stage of labour (epidural group), while the remaining mothers (who were given pethidine for pain relief, if necessary) acted as a control group. In the epidural group the patients had only minimal changes in acid-base balance and lactate concentration during the first stage. During the second stage lactate concentration increased. In the control group, on the other hand, the acid-base balance showed signs of hyperventilation and lactic acid accumulation during the first stage. The potassium changes were quite minimal and were not significantly different between the groups. The CPK level did not change during labour, but 2 and 4 h after delivery it was significantly elevated in both groups. The foetal acid-base balance, potassium, lactate and PaO2 values revealed no differences between the groups at any time. The CPK level in umbilical venous blood was significantly higher in the epidural group.
在28例引产过程中，对母胎酸碱平衡、动脉血氧分压（PaO2）、乳酸、钾和肌酸磷酸激酶（CPK）进行了研究。每第二位产妇在第一产程接受节段性硬膜外镇痛（硬膜外组），其余产妇（必要时给予哌替啶止痛）作为对照组。硬膜外组患者在第一产程中酸碱平衡和乳酸浓度仅有轻微变化。第二产程中乳酸浓度升高。另一方面，对照组在第一产程中酸碱平衡显示有过度通气和乳酸蓄积的迹象。钾的变化非常轻微，两组之间无显著差异。分娩过程中CPK水平未发生变化，但两组在产后2小时和4小时均显著升高。两组胎儿的酸碱平衡、钾、乳酸和PaO2值在任何时候均无差异。硬膜外组脐静脉血中的CPK水平显著更高。
