Tejedor J, Rodríguez J M
Department of Ophthalmology, Hospital Ramón y Cajal, Madrid, Spain.
Br J Ophthalmol. 1998 Feb;82(2):110-4. doi: 10.1136/bjo.82.2.110.
Two viable options were compared, reoperation and botulinum toxin injection, in the management of children who need retreatment after surgery for acquired esotropia.
47 strabismic children previously operated to correct an acquired esotropia were randomised to reoperation or botulinum toxin injection. Reoperation was undertaken in 24 of these patients and botulinum toxin injection in 23 of them. The percentage net change in distance deviation, the percentage of patients with successful motor outcome, detectable fusion, and stereopsis were compared 1 year after retreatment and at last visit (average follow up: 2.9 years in reoperation group, and 2.7 years in botulinum group). The motor success rate relative to time elapsed from initial surgery was evaluated.
There was no significant difference in the motor and sensory outcomes between patients reoperated and treated with botulinum injection. The frequency of correction to within 8 prism dioptres of orthotropia was, respectively: 75% versus 69.56% at 1 year; 70.83% versus 60.86% at last visit. Botulinum injection could be more effective when performed within 3 months of initial surgery.
Botulinum injection is a rapid and safe procedure that may be as effective as reoperation in the management of children who need a secondary procedure after surgery for acquired esotropia.
比较两种可行的治疗方法,即再次手术和肉毒杆菌毒素注射,用于治疗后天性内斜视手术后需要再次治疗的儿童。
47名曾接受手术矫正后天性内斜视的斜视儿童被随机分为再次手术组或肉毒杆菌毒素注射组。其中24例患者接受再次手术,23例接受肉毒杆菌毒素注射。在再次治疗后1年和最后一次随访时(再次手术组平均随访2.9年,肉毒杆菌毒素组平均随访2.7年),比较远距离斜视度的净变化百分比、运动结果成功的患者百分比、可检测到的融合以及立体视。评估相对于初次手术时间的运动成功率。
再次手术患者和接受肉毒杆菌毒素注射治疗的患者在运动和感觉结果方面没有显著差异。在1年时,矫正至正交性8棱镜度以内的频率分别为:75%对69.56%;在最后一次随访时为70.83%对60.86%。在初次手术后3个月内进行肉毒杆菌毒素注射可能更有效。
肉毒杆菌毒素注射是一种快速且安全的治疗方法,在治疗后天性内斜视手术后需要二次手术的儿童方面可能与再次手术同样有效。