Hardell L, Axelson O
Department of Oncology, Orebro Medical Center, Sweden.
Oncol Res. 1998;10(1):1-5.
Immunosuppression, possibly in combination with viruses, could be a main etiologic mechanism for non-Hodgkin's lymphoma (NHL). Chemicals such as phenoxyacetic acids, chlorophenols, dioxins, organic solvents, polychlorinated biphenyls, chlordane, and immunosuppressive drugs have been associated with this disease. Also UV light and blood transfusion have been postulated to be risk factors. Conclusive evidence of a causal association with NHL is not established for all of these exposures, but experimental evidence and clinical observations indicate that all these exposures have in common that they may impair the immune system. Furthermore, acquired and congenital immune deficiency as well as autoimmune disorders increase the risk for NHL. In view of currently available evidence, the first priority for reducing morbidity due to NHL might be to take action against adverse chemical exposures as a measure that is more easily achievable than any other kind of prevention.
免疫抑制，可能与病毒共同作用，可能是非霍奇金淋巴瘤（NHL）的主要病因机制。苯氧乙酸、氯酚、二恶英、有机溶剂、多氯联苯、氯丹等化学物质以及免疫抑制药物都与这种疾病有关。此外，紫外线照射和输血也被认为是危险因素。并非所有这些暴露与NHL之间的因果关系都有确凿证据，但实验证据和临床观察表明，所有这些暴露的共同之处在于它们可能损害免疫系统。此外，获得性和先天性免疫缺陷以及自身免疫性疾病会增加患NHL的风险。鉴于目前可得的证据，降低NHL发病率的首要任务可能是采取行动应对有害化学物质暴露，这是一种比任何其他预防措施都更容易实现的措施。
