Fritschi Lin, Benke Geza, Hughes Ann M, Kricker Anne, Vajdic Claire M, Grulich Andrew, Turner Jennifer, Milliken Samuel, Kaldor John, Armstrong Bruce K
School of Population Health, University of Western Australia, Perth, Australia.
Cancer Causes Control. 2005 Jun;16(5):599-607. doi: 10.1007/s10552-004-7845-0.
Several studies have suggested that there is an occupational component to the causation of non-Hodgkin lymphoma (NHL). We aimed to use accurate means to assess occupational exposures to solvents, metals, organic dusts and polychlorinated biphenyls (PCBs) in a case-control study.
Cases were incident NHLs during 2000 and 2001 in two regions of Australia. Controls were randomly selected from the electoral roll and frequency matched to cases by age, sex and region. A detailed occupational history was taken from each subject. For jobs with likely exposure to the chemicals of interest, additional questions were asked by telephone interview using modified job specific modules. An expert allocated exposures using the information in the job histories and the interviews. Odds ratios were calculated for each exposure adjusting for age, sex, region and ethnic origin.
694 cases and 694 controls (70 and 45 respectively of those potentially eligible) participated. The risk of NHL was increased by about 30 for exposure to any solvent with a dose response relationship, subgroup analysis showed the finding was restricted to solvents other than benzene. Exposure to wood dust also increased the risk of NHL slightly. Exposures to other organic dusts, metals, and PCBs were not strongly related to NHL.
The risk of NHL appears to be increased by exposure to solvents other than benzene and possibly to wood dust.
多项研究表明，非霍奇金淋巴瘤（NHL）的病因存在职业因素。我们旨在通过精确方法评估一项病例对照研究中职业性接触溶剂、金属、有机粉尘和多氯联苯（PCBs）的情况。
病例为2000年和2001年澳大利亚两个地区的新发NHL患者。对照从选民名册中随机选取，并按年龄、性别和地区与病例进行频数匹配。对每个受试者进行详细的职业史调查。对于可能接触相关化学物质的工作，通过电话访谈使用经过修改的特定工作模块提出额外问题。一位专家根据职业史和访谈中的信息分配接触情况。计算每种接触情况的比值比，并对年龄、性别、地区和种族进行校正。
694例病例和694例对照（分别有70例和45例为潜在合格对象）参与研究。接触任何溶剂且存在剂量反应关系时，NHL风险增加约30倍，亚组分析显示该结果仅限于苯以外的溶剂。接触木尘也使NHL风险略有增加。接触其他有机粉尘、金属和多氯联苯与NHL无强烈关联。
接触苯以外的溶剂以及可能接触木尘似乎会增加NHL风险。
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