Puppi A, Szalay L, Dely M
Acta Biochim Biophys Acad Sci Hung. 1976;11(1):63-73.
By simultaneous recording of myograms, cardiomyograms and tissue redox state potentials (RSP) it was established that in tissues with higher RSP levels (+170 mV or more; rectus muscle, smooth muscle of the stomach) acetylcholine (Ach) exerted a depolarizing type of action, while in the frog heart ventricle (with RSP values lower than +170 mV) the mediator triggered a hyperpolarizing type Ach effect. Since following an appropriate adjustment of RSP values by exogenous redox agents the depolarizing and/or hyperpolarizing Ach effects can be modelled on any organs, independently of the original type of effect of Ach, it may be assumed that the existing redox state plays an important role in the determination of the depolarizing and/or hyperpolarizing effect of Ach.
通过同步记录肌电图、心肌电图和组织氧化还原状态电位（RSP），确定在RSP水平较高（+170mV或更高；直肌、胃平滑肌）的组织中，乙酰胆碱（Ach）发挥去极化作用，而在蛙心心室（RSP值低于+170mV）中，该介质引发超极化型Ach效应。由于通过外源性氧化还原剂适当调节RSP值后，去极化和/或超极化Ach效应可在任何器官上模拟，而与Ach的原始效应类型无关，因此可以假设现有的氧化还原状态在确定Ach的去极化和/或超极化效应中起重要作用。
