Hirano T, Morris H P, Jackson C M, Lewis J W
Acta Pathol Jpn. 1976 May;26(3):341-56. doi: 10.1111/j.1440-1827.1976.tb00884.x.
N,N'2-2,7-Flourenylenebisacetamide (2.7-FAA) was administered orally to 34 female, strain AXC/I rats. Nineteen were pretreated with the extirpation of the salivary glands. The remaining 15 rats received no surgical treatment. Six of these 15 unoperated rats developed mammary carcinomas and seven developed tumors at other sites, whereas none of 19 operated rats had mammary tumors but 8 rats had tumors at other sites. No tumor developed in 4 operated control rats that were on normal diet. The results demonstrate that pretreatment with extirpation of the salivary glands inhibited mammary tumor induction in rats by 2,7-FAA although it did not inhibit induction of other type tumors. The mechanism by which induction of mammary tumors was inhibited is not clear. Ovarian atrophy and hepatic necrosis were observed in both operated and unoperated rats ingesting 2,7-FAA but did not seem to affect carcinogenesis by the carcinogen. Lower body weight was observed in operated rats but it is not considered to be the major cause of a complete inhibition of mammary tumor induction.
将N，N'2-2，7-芴撑二乙酰胺（2.7-FAA）经口给予34只雌性AXC/I品系大鼠。其中19只预先进行了唾液腺切除。其余15只大鼠未接受手术治疗。这15只未手术的大鼠中有6只发生了乳腺癌，7只在其他部位发生了肿瘤，而19只手术大鼠中无一发生乳腺肿瘤，但有8只在其他部位发生了肿瘤。4只食用正常饮食的手术对照大鼠未发生肿瘤。结果表明，唾液腺切除预处理可抑制2,7-FAA对大鼠乳腺肿瘤的诱导，尽管它并不抑制其他类型肿瘤的诱导。乳腺肿瘤诱导受到抑制的机制尚不清楚。在摄入2,7-FAA的手术和未手术大鼠中均观察到卵巢萎缩和肝坏死，但这似乎并不影响致癌物的致癌作用。手术大鼠体重较低，但这不被认为是乳腺肿瘤诱导完全抑制的主要原因。
