Peat M A
LabOne, Inc., Lenexa, Kansas, USA.
Clin Lab Med. 1998 Jun;18(2):263-78.
Over the last 15 years there have been many changes in the practice of forensic toxicology. One of the most noteworthy has been the recognition of the need for good laboratory practices in the forensic toxicology laboratory. This has resulted in the development of an accreditation program for laboratories. Increasingly, forensic toxicologists are asked to interpret results in driving under the influence of drug cases. These interpretations are also difficult because of the lack of data correlating blood (or plasma) concentrations with impairment. The development of newer immunoassays and hyphenated mass spectrometric techniques now allow the forensic toxicologist to assay a large number of drugs (both traditional and products of the biotechnology revolution) with increasing sensitivity. This article focuses on these changes and some of the challenges facing the forensic toxicologists of the 21st century.
在过去的15年里，法医毒理学实践发生了许多变化。其中最值得注意的一点是，人们认识到法医毒理学实验室需要良好的实验室规范。这导致了实验室认可计划的制定。越来越多的法医毒理学家被要求在药物影响下驾驶案件中解释检测结果。由于缺乏将血液（或血浆）浓度与损伤相关联的数据，这些解释也很困难。更新的免疫分析和联用质谱技术的发展，现在使法医毒理学家能够以越来越高的灵敏度检测大量药物（包括传统药物和生物技术革命的产物）。本文重点关注这些变化以及21世纪法医毒理学家面临的一些挑战。
