Grossi L, Ciccaglione A F, Travaglini N, Marzio L
School of Gastroenterology, G.D'Annunzio University, Pescara, Italy.
Neurogastroenterol Motil. 1998 Apr;10(2):115-21. doi: 10.1046/j.1365-2982.1998.00094.x.
the motor aspects underlying gastro-oesophageal reflux disease (GORD) are still not completely clear.
to evaluate the relationship between oesophageal and gastric motility in GORD patients.
twelve patients with grade I-II oesophagitis, mean age 45 yr, and 10 healthy subjects, mean age 42 yr, were studied.
a pH-manometry was performed to analyse oesophageal and gastric motility, swallows and oesophageal pH values for the whole 24-h period, and for the 2-min period before and after each reflux episode.
as compared to controls, GORD patients showed in the 24-h period, a greater number of swallows (P < 0.01) and a lower percentage of post deglutitive propagated oesophageal body waves (P < 0.05). The number of migrating motor complexes (MMC) was similar in the two groups, with a lower amplitude of phase III gastric waves in GORD. During MMC reflux episodes were seen only in GORD patients. After refluxes an increase in swallows, simultaneous and secondary oesophageal waves were detected in GORD patients, with a reduction of primary peristalsis. Isolated gastric contractions preceded reflux episodes more frequently in GORD patients than in controls.
GORD patients showed an increase in swallows with altered post-deglutitive oesophageal motility and a reduced amplitude of gastric MMC. Moreover small contractions of gastric antrum are present before acid refluxes, suggesting a multifactorial pathogenesis of the disease.
胃食管反流病（GORD）潜在的运动方面仍不完全清楚。
评估GORD患者食管和胃动力之间的关系。
研究了12例患有I-II级食管炎的患者，平均年龄45岁，以及10名健康受试者，平均年龄42岁。
进行pH值测压法，分析食管和胃动力、24小时内的吞咽次数和食管pH值，以及每次反流发作前后2分钟内的情况。
与对照组相比，GORD患者在24小时内吞咽次数更多（P < 0.01），吞咽后食管体部传播波的百分比更低（P < 0.05）。两组的移行运动复合波（MMC）数量相似，但GORD患者的胃III期波振幅较低。仅在GORD患者的MMC期间观察到反流发作。反流后，GORD患者的吞咽次数增加，同时出现同步和继发性食管波，原发性蠕动减少。与对照组相比，GORD患者反流发作前孤立的胃收缩更为频繁。
GORD患者吞咽次数增加，吞咽后食管动力改变，胃MMC振幅降低。此外，酸反流前胃窦有小收缩，提示该病的发病机制是多因素的。
