一名弥漫性大B细胞淋巴瘤患者中与BCL-6基因重排相关的（3；16）（q27；p11）易位。

Translocation (3;16)(q27;p11) in a patient with diffuse large B-cell lymphoma associated with the BCL-6 gene rearrangement.

作者信息

Ichinohasama R, Miura I, Shishido T, Matsumoto K, Shimizu Y, Miki T, DeCoteau J F, Kadin M E, Ooya K

机构信息

Department of Oral Pathology, Tohoku University School of Dentistry, Sendai, Japan.

出版信息

Cancer Genet Cytogenet. 1998 Jun;103(2):133-9. doi: 10.1016/s0165-4608(97)00390-7.

DOI:10.1016/s0165-4608(97)00390-7

PMID:9614912

Abstract

A patient with B-cell lineage diffuse large-cell lymphoma carrying the t(3;16)(q27;p11) and BCL-6 rearrangement is described. Cytogenetic studies showed 46,XY,t(3;16)(q27;p11.2)[.11]/46,idem,add(18)(q21)[7]/46,XY[2]. The chromosomal translocation involving the 3q27 locus was associated with the BCL-6 gene rearrangement identified by Southern blot analysis. This case involved systemic lymph nodes, as large as 3 cm in diameter, bilaterally in neck, axilla, and inguinal regions. The patient obtained complete remission with chemotherapy.

摘要

描述了一名携带t(3;16)(q27;p11)和BCL-6重排的B细胞系弥漫性大细胞淋巴瘤患者。细胞遗传学研究显示46,XY,t(3;16)(q27;p11.2)[.11]/46,同型,add(18)(q21)[7]/46,XY[2]。通过Southern印迹分析鉴定，涉及3q27位点的染色体易位与BCL-6基因重排相关。该病例累及全身淋巴结，直径达3厘米，双侧颈部、腋窝和腹股沟区均有。患者通过化疗获得完全缓解。