Molecular analysis of human immunoglobulin heavy chain variable genes (IgVH) in normal and malignant B cells.
作者信息
Müller-Hermelink H K, Greiner A
机构信息
Institute of Pathology, University of Würzburg, Germany.
出版信息
Am J Pathol. 1998 Nov;153(5):1341-6. doi: 10.1016/S0002-9440(10)65718-5.
Abstract
摘要
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Molecular analysis of human immunoglobulin heavy chain variable genes (IgVH) in normal and malignant B cells.正常和恶性B细胞中人免疫球蛋白重链可变基因（IgVH）的分子分析。
Am J Pathol. 1998 Nov;153(5):1341-6. doi: 10.1016/S0002-9440(10)65718-5.
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本文引用的文献
1
Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation.免疫球蛋白VH基因的突变分析表明，原发性渗出性淋巴瘤源自B细胞成熟的不同阶段。
Am J Pathol. 1998 Nov;153(5):1609-14. doi: 10.1016/S0002-9440(10)65749-5.
2
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.通过Ig基因的体细胞高频突变过程，正常B细胞中的BCL-6基因突变。
Science. 1998 Jun 12;280(5370):1750-2. doi: 10.1126/science.280.5370.1750.
3
Translocation (3;16)(q27;p11) in a patient with diffuse large B-cell lymphoma associated with the BCL-6 gene rearrangement.一名弥漫性大B细胞淋巴瘤患者中与BCL-6基因重排相关的（3；16）（q27；p11）易位。
Cancer Genet Cytogenet. 1998 Jun;103(2):133-9. doi: 10.1016/s0165-4608(97)00390-7.
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Somatic hypermutation in normal and transformed human B cells.正常和转化的人B细胞中的体细胞高频突变
Immunol Rev. 1998 Apr;162:261-80. doi: 10.1111/j.1600-065x.1998.tb01447.x.
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Mutation of the 5' noncoding region of the BCL-6 gene in low-grade gastric lymphoma of the mucosa-associated lymphoid tissue.黏膜相关淋巴组织低度胃淋巴瘤中BCL-6基因5'非编码区的突变
Cancer Genet Cytogenet. 1998 Apr 15;102(2):110-3. doi: 10.1016/s0165-4608(97)00353-1.
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Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease.体细胞高频突变过程中缺失和重复的频繁发生：对癌基因易位和重链病的影响
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Somatic hypermutation of immunoglobulin genes is linked to transcription.免疫球蛋白基因的体细胞超突变与转录相关。
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Mismatch repair co-opted by hypermutation.错配修复被高突变所利用。
Science. 1998 Feb 20;279(5354):1207-10. doi: 10.1126/science.279.5354.1207.
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