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1
Molecular analysis of human immunoglobulin heavy chain variable genes (IgVH) in normal and malignant B cells.正常和恶性B细胞中人免疫球蛋白重链可变基因（IgVH）的分子分析。
Am J Pathol. 1998 Nov;153(5):1341-6. doi: 10.1016/S0002-9440(10)65718-5.
2
IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution.里氏转化的免疫球蛋白重链可变区（IgVH）突变状态及克隆性分析：弥漫性大B细胞淋巴瘤和霍奇金淋巴瘤合并B细胞慢性淋巴细胞白血病（B-CLL）代表了两种不同的疾病演变途径。
Am J Surg Pathol. 2007 Oct;31(10):1605-14. doi: 10.1097/PAS.0b013e31804bdaf8.
3
V(H) gene analysis of hairy cell leukemia reveals a homogeneous mutation status and suggests its marginal zone B-cell origin.毛细胞白血病的V(H)基因分析揭示了其均一的突变状态，并提示其起源于边缘区B细胞。
Leukemia. 2004 Oct;18(10):1729-32. doi: 10.1038/sj.leu.2403503.
4
AIDS primary central nervous system lymphoma: molecular analysis of the expressed VH genes and possible implications for lymphomagenesis.艾滋病相关原发性中枢神经系统淋巴瘤：表达的VH基因的分子分析及其对淋巴瘤发生的可能影响。
J Immunol. 1999 Feb 1;162(3):1551-8.
5
Primary cutaneous B-cell lymphoma is associated with somatically hypermutated immunoglobulin variable genes and frequent use of VH1-69 and VH4-59 segments.原发性皮肤 B 细胞淋巴瘤与体细胞超突变免疫球蛋白可变基因相关，并且频繁使用 VH1-69 和 VH4-59 片段。
Br J Dermatol. 2010 Mar;162(3):611-8. doi: 10.1111/j.1365-2133.2009.09576.x. Epub 2009 Nov 10.
6
Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human.分子免疫球蛋白基因分析显示，单核细胞样B细胞淋巴瘤是一种携带体细胞突变V区基因的成熟B细胞恶性肿瘤，并提示κ-缺失元件的重排（导致免疫球蛋白κ增强子缺失）会消除人类中的体细胞超突变。
Eur J Immunol. 1996 Aug;26(8):1794-800. doi: 10.1002/eji.1830260820.
7
Analysis of VH genes in 49 marginal zone lymphoma cases reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection.对49例边缘区淋巴瘤病例的VH基因分析显示，脾脏肿瘤和淋巴结肿瘤之间存在显著异质性，并提示存在克隆选择。
Haematologica. 2005 Apr;90(4):435.
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A new subgroup of immunoglobulin heavy chain variable region genes for the assessment of clonality in feline B-cell lymphomas.用于评估猫B细胞淋巴瘤克隆性的免疫球蛋白重链可变区基因的一个新亚组。
Vet Immunol Immunopathol. 2009 Jul 15;130(1-2):59-69. doi: 10.1016/j.vetimm.2009.01.006. Epub 2009 Feb 24.
9
Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene.伴有涉及BCL11A基因的t(2;14)(p13;q32)易位的淋巴系统恶性肿瘤中IG V(H)基因的体细胞超突变缺失。
Leukemia. 2002 May;16(5):937-9. doi: 10.1038/sj.leu.2402480.
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[Organization of the human immunoglobulin heavy chain variable regions genes].[人类免疫球蛋白重链可变区基因的组织]
Tanpakushitsu Kakusan Koso. 1993 Feb;38(3):412-9.

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Transdifferentiation of Multiple Myeloma into Histiocytic Sarcoma: Case Report of a Highly Unusual Phenomenon.多发性骨髓瘤向组织细胞肉瘤的转分化：一种高度罕见现象的病例报告
Pathobiology. 2025 Jun 8:1-11. doi: 10.1159/000546669.
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Two Pathways of p27 Degradation Are Required for Murine Lymphoma Driven by Myc and EBV Latent Membrane Protein 2A.两种 p27 降解途径对于 Myc 和 EBV 潜伏膜蛋白 2A 驱动的小鼠淋巴瘤是必需的。
mBio. 2019 Apr 16;10(2):e00548-19. doi: 10.1128/mBio.00548-19.
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A rare case of signet ring cell lymphoma: Diagnosis aided by immunofluorescent staining.一例罕见的印戒细胞淋巴瘤：免疫荧光染色辅助诊断
J Cytol. 2017 Jan-Mar;34(1):56-58. doi: 10.4103/0970-9371.197622.
4
Simultaneous evaluation of T- and B-cell clonality, t(11;14) and t(14;18), in a single reaction by a four-color multiplex polymerase chain reaction assay and automated high-resolution fragment analysis: a method for the rapid molecular diagnosis of lymphoproliferative disorders applicable to fresh frozen and formalin-fixed, paraffin-embedded tissues, blood, and bone marrow aspirates.通过四色多重聚合酶链反应分析和自动高分辨率片段分析在单一反应中同时评估T细胞和B细胞克隆性、t(11;14)和t(14;18)：一种适用于新鲜冷冻和福尔马林固定、石蜡包埋组织、血液和骨髓穿刺液的淋巴增殖性疾病快速分子诊断方法。
Am J Pathol. 2001 Dec;159(6):2031-43. doi: 10.1016/S0002-9440(10)63055-6.
5
The characteristics of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma: comparison between EBV(+) and EBV(-) cases in Japanese population.爱泼斯坦-巴尔病毒（EBV）阳性弥漫性大B细胞淋巴瘤的特征：日本人群中EBV（+）和EBV（-）病例的比较。
Jpn J Cancer Res. 2000 Dec;91(12):1233-40. doi: 10.1111/j.1349-7006.2000.tb00909.x.

本文引用的文献

1
Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation.免疫球蛋白VH基因的突变分析表明，原发性渗出性淋巴瘤源自B细胞成熟的不同阶段。
Am J Pathol. 1998 Nov;153(5):1609-14. doi: 10.1016/S0002-9440(10)65749-5.
2
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.通过Ig基因的体细胞高频突变过程，正常B细胞中的BCL-6基因突变。
Science. 1998 Jun 12;280(5370):1750-2. doi: 10.1126/science.280.5370.1750.
3
Translocation (3;16)(q27;p11) in a patient with diffuse large B-cell lymphoma associated with the BCL-6 gene rearrangement.一名弥漫性大B细胞淋巴瘤患者中与BCL-6基因重排相关的（3；16）（q27；p11）易位。
Cancer Genet Cytogenet. 1998 Jun;103(2):133-9. doi: 10.1016/s0165-4608(97)00390-7.
4
Somatic hypermutation in normal and transformed human B cells.正常和转化的人B细胞中的体细胞高频突变
Immunol Rev. 1998 Apr;162:261-80. doi: 10.1111/j.1600-065x.1998.tb01447.x.
5
Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression.滤泡性淋巴瘤和弥漫性淋巴瘤中VH基因的分析显示，在疾病早期存在持续的体细胞突变和多种同种型转录本，且在疾病进展过程中发生变化。
Blood. 1998 Jun 1;91(11):4292-9.
6
Mutation of the 5' noncoding region of the BCL-6 gene in low-grade gastric lymphoma of the mucosa-associated lymphoid tissue.黏膜相关淋巴组织低度胃淋巴瘤中BCL-6基因5'非编码区的突变
Cancer Genet Cytogenet. 1998 Apr 15;102(2):110-3. doi: 10.1016/s0165-4608(97)00353-1.
7
Immunoglobulin VH genes of high-grade mucosa-associated lymphoid tissue lymphomas show a high load of somatic mutations and evidence of antigen-dependent affinity maturation.高级别黏膜相关淋巴组织淋巴瘤的免疫球蛋白VH基因显示出高负荷的体细胞突变以及抗原依赖性亲和力成熟的证据。
Lab Invest. 1998 Mar;78(3):277-87.
8
Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease.体细胞高频突变过程中缺失和重复的频繁发生：对癌基因易位和重链病的影响
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2463-8. doi: 10.1073/pnas.95.5.2463.
9
Somatic hypermutation of immunoglobulin genes is linked to transcription.免疫球蛋白基因的体细胞超突变与转录相关。
Curr Top Microbiol Immunol. 1998;229:11-9. doi: 10.1007/978-3-642-71984-4_2.
10
Mismatch repair co-opted by hypermutation.错配修复被高突变所利用。
Science. 1998 Feb 20;279(5354):1207-10. doi: 10.1126/science.279.5354.1207.

Molecular analysis of human immunoglobulin heavy chain variable genes (IgVH) in normal and malignant B cells.

作者信息

Müller-Hermelink H K, Greiner A

机构信息

Institute of Pathology, University of Würzburg, Germany.

出版信息

Am J Pathol. 1998 Nov;153(5):1341-6. doi: 10.1016/S0002-9440(10)65718-5.

DOI:10.1016/S0002-9440(10)65718-5
PMID:9811322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1853421/
Abstract
摘要