Ban S, Toyonaga A, Harada H, Ikejiri N, Tanikawa K
Dept. of Medicine II, Kurume University School of Medicine, Japan.
Endoscopy. 1998 Mar;30(3):253-7. doi: 10.1055/s-2007-1001251.
A retrospective epidemiological investigation has demonstrated that alcohol abuse is a major risk factor for esophageal cancer. However, prospective endoscopic screening for early detection in heavy drinkers is not available at present.
A prospective study was conducted that included 255 alcoholics (aged 52 +/- 9 years). The patients were consecutively screened using esophagoscopy with iodine staining and targeted biopsy. The study also explored whether there was a relationship between the amount of alcohol intake and the detection rate of esophageal cancer.
Unstained lesions (larger than 5 mm) were observed on the esophageal wall in 55 patients (21.6%). Ten patients (3.9%) with 13 lesions were found to have esophageal cancer of the superficial type, with no symptoms. Cancer invasion was confined to the epithelium in three patients, to the lamina propria in seven, and to the submucosa in three. There was a direct relationship between substantial alcohol intake and the presence of esophageal cancer.
Screening esophagoscopy with iodine staining is very advantageous in detecting esophageal cancer at an early stage.
一项回顾性流行病学调查表明，酗酒是食管癌的主要危险因素。然而，目前尚无针对重度饮酒者进行前瞻性内镜筛查以早期发现食管癌的方法。
开展了一项前瞻性研究，纳入255名酗酒者（年龄52±9岁）。对患者连续进行食管镜碘染色检查及靶向活检。该研究还探讨了酒精摄入量与食管癌检出率之间是否存在关联。
55例患者（21.6%）食管壁上观察到未染色病变（大于5毫米）。10例患者（3.9%）有13处病变，被发现患有浅表型食管癌，且无症状。3例患者癌浸润局限于上皮层，7例局限于固有层，3例局限于黏膜下层。大量饮酒与食管癌的存在有直接关系。
碘染色食管镜筛查在早期发现食管癌方面非常有优势。
