Viskin S, Fish R, Roth A, Copperman Y
Department of Cardiology, Sourasky-Tel Aviv Medical Center, Tel Aviv University, Israel.
Heart. 1998 Apr;79(4):417-9. doi: 10.1136/hrt.79.4.417.
Torsade de pointes in the congenital long QT syndrome (LQTS) is often pause dependent. Thus, the main goal of pacemaker treatment in the LQTS may be the prevention of pauses that facilitate the onset of torsade de pointes. A pause prevention pacing algorithm (rate smoothing) was used for arrhythmia prevention in a 14 year old girl with congenital LQTS. By temporarily increasing the pacing rate after spontaneous premature beats, rate smoothing down of 18% prevented postextrasystolic pauses, pause related T-U changes, and recurrence of pause induced torsade de pointes. Rate smoothing is a potentially useful tool that ought to be evaluated for the prevention of torsade de pointes in the LQTS.
先天性长QT综合征（LQTS）中的尖端扭转型室速通常与停顿有关。因此，LQTS起搏器治疗的主要目标可能是预防促发尖端扭转型室速发作的停顿。在一名14岁先天性LQTS女孩中，采用停顿预防起搏算法（心率平滑）预防心律失常。通过在自发性早搏后暂时提高起搏频率，18%的心率平滑降低预防了早搏后停顿、停顿相关的T波-U波改变以及停顿诱发的尖端扭转型室速复发。心率平滑是一种潜在有用的工具，应该对其在预防LQTS患者尖端扭转型室速方面进行评估。
