Petersson I F, Boegård T, Dahlström J, Svensson B, Heinegård D, Saxne T
Spenshult's Hospital for Rheumatic Diseases, Halmstad, Sweden.
Osteoarthritis Cartilage. 1998 Jan;6(1):33-9. doi: 10.1053/joca.1997.0090.
To study the relations between knee joint abnormalities, reflected by bone scintigraphy and serum concentrations of cartilage oligomeric matrix protein (COMP) and bone sialoprotein (BSP).
In a group of 38 individuals aged 37-54 years with chronic knee pain for more than four years, both knees were investigated with bone scan. The bone scans were graded for the extent of abnormalities. Radiographs of both knees were graded for tibiofemoral and patellofemoral osteoarthritis (OA). Serum levels of COMP and BSP were measured by immunoassays.
Bone scan abnormalities were detected in 26/38 individuals and radiographic OA in 23/38 individuals. The serum concentrations of COMP and BSP were significantly higher in the individuals with bone scan abnormalities (P = 0.02 and P = 0.004, respectively). In addition, the serum levels of COMP correlated positively with the extent of bone scan abnormalities (N = 38), r = 0.56, P = 0.002. Serum BSP did not correlate to the extent of scan abnormalities.
In individuals with knee pain, serum levels of COMP and BSP differ between those with or without bone scan abnormalities in the knee joints. This suggests that measurements of the serum levels of these markers have potential as means for evaluation of tissue changes in individuals with long standing knee pain in relation to early stages of OA.
研究骨闪烁显像所反映的膝关节异常与软骨寡聚基质蛋白（COMP）和骨唾液酸蛋白（BSP）血清浓度之间的关系。
在一组37 - 54岁、慢性膝关节疼痛超过四年的38名个体中，对双膝进行骨扫描检查。根据异常程度对骨扫描结果进行分级。对双膝X线片进行胫股关节和髌股关节骨关节炎（OA）分级。通过免疫测定法测量血清中COMP和BSP的水平。
38名个体中，26人检测到骨扫描异常，23人检测到X线片显示OA。骨扫描异常个体的血清COMP和BSP浓度显著更高（分别为P = 0.02和P = 0.004）。此外，血清COMP水平与骨扫描异常程度呈正相关（N = 38），r = 0.56，P = 0.002。血清BSP与扫描异常程度无相关性。
在膝关节疼痛个体中，膝关节有或无骨扫描异常者的血清COMP和BSP水平存在差异。这表明，测量这些标志物的血清水平有可能作为评估长期膝关节疼痛个体与OA早期相关的组织变化的手段。
