Petersson I F, Boegård T, Svensson B, Heinegård D, Saxne T
Spenshult's Hospital for Rheumatic Diseases, Oskarström, Sweden.
Br J Rheumatol. 1998 Jan;37(1):46-50. doi: 10.1093/rheumatology/37.1.46.
Serum concentrations of two extracellular matrix molecules were determined over a 3 yr period in individuals with chronic knee pain to investigate whether sequential serum measurements of cartilage- and bone-derived molecular fragments reflect early stages of osteoarthritis (OA) of the knee joints. Thirty-eight individuals with chronic knee pain (> 3 months at inclusion) with or without radiographic evidence of knee joint OA at the 3 yr follow-up radiographic examination were studied. Serum concentrations of cartilage oligomeric matrix protein (COMP) and bone sialoprotein (BSP) increased significantly (P < 0.001) in the 23 individuals with radiographic OA at follow-up, while remaining unchanged in the 15 individuals with normal radiographs at follow-up. The baseline concentrations of the two variables did not differ between the groups. These findings suggest that pathological processes in cartilage and subchondral bone coincide in OA, and appear to be reflected by circulating levels of macromolecules released from cartilage and bone. Changes in serum levels of COMP and BSP are potential tools in studies of knee joint OA in subjects with chronic knee pain.
在3年时间里，对患有慢性膝关节疼痛的个体测定了两种细胞外基质分子的血清浓度，以研究对软骨和骨衍生分子片段进行连续血清检测是否能反映膝关节骨关节炎（OA）的早期阶段。研究对象为38名患有慢性膝关节疼痛（入组时疼痛超过3个月）的个体，在3年随访影像学检查时，这些个体有无膝关节OA的影像学证据。随访时，23名有影像学OA的个体血清中软骨寡聚基质蛋白（COMP）和骨唾液酸蛋白（BSP）浓度显著升高（P<0.001），而15名随访时X线片正常的个体中这两种蛋白浓度保持不变。两组间这两个变量的基线浓度无差异。这些发现表明，OA中软骨和软骨下骨的病理过程是一致的，并且似乎可通过从软骨和骨释放的大分子的循环水平反映出来。COMP和BSP血清水平的变化是研究慢性膝关节疼痛患者膝关节OA的潜在工具。
