Abu-Elyazeed R R, Mansour N S, Youssef F G, Boghdadi A M, el Khoby T A, Hassanein Y A, el Gamal R R
U.S. Naval Medical Research Unit No. 3, Cairo, Egypt.
J Egypt Soc Parasitol. 1998 Apr;28(1):1-7.
During October-November 1991, 1356 male farmers, 18-40 years old from a village in Fayoum Governorate, Egypt, were examined for Schistosoma haematobium infection. The prevalence of infection was 22.2%. Infected farmers were treated immediately with praziquantel at the recommended dose of 40 mg/kg body weight in a single, oral dose. Twelve weeks after treatment 86/262 (32.8%) infected farmers were negative for S. haematobium eggs in urine. In another study conducted in a satellite village in the Nile Delta (Beheira Governorate) where S. mansoni infection is prevalent, all residents of both sexes between 5 and 50 years of age (n = 858) were examined for S. mansoni. The prevalence of S. mansoni was 69.0%. Infected subjects were treated with the same dose of praziquantel during January-February 94, with an overall resultant efficacy of 85.5% (471/551) and 97.2% (103/106) in 18-40 years old males 8-10 weeks post treatment. The high cure rate in the second study was probably because treatment took place 2 months after the end of the high transmission season.
1991年10月至11月期间，对埃及法尤姆省一个村庄的1356名年龄在18至40岁之间的男性农民进行了埃及血吸虫感染检查。感染率为22.2%。对感染的农民立即采用吡喹酮进行治疗，推荐剂量为40毫克/千克体重，单次口服。治疗12周后，86/262（32.8%）名感染的农民尿液中埃及血吸虫卵呈阴性。在另一项在尼罗河三角洲（贝赫拉省）一个卫星村进行的研究中，曼氏血吸虫感染流行，对所有年龄在5至50岁之间的男女居民（n = 858）进行了曼氏血吸虫检查。曼氏血吸虫感染率为69.0%。1994年1月至2月期间，对感染的受试者采用相同剂量的吡喹酮进行治疗，在治疗后8至10周，18至40岁男性的总体有效率分别为85.5%（471/551）和97.2%（103/106）。第二项研究中的高治愈率可能是因为治疗在高传播季节结束2个月后进行。
