Kocyigit A, Erel O, Seyrek A, Gurel M S, Aktepe N, Avci S, Vural H
Department of Biochemistry, Faculty of Harran University, Sanliurfa, Turkey.
J Egypt Soc Parasitol. 1998 Apr;28(1):133-42.
The effects of cutaneous leishmaniasis (CL) infections on total content of the essential trace elements and alterations of these elements content during antimonial therapy, serum iron (Fe), copper (Cu) and zinc (Zn), were determined in 40 patients with CL. 32 healthy subjects were selected as control group. Pentavalent antimonial compounds (Glucantime) were given intramuscularly (20 mg/kg/day) for three weeks in patients group. Serum Cu and Zn levels were determined by flame atomic absorption spectrometry and Fe levels were determined by colorimetrically. Before antimonial therapy; Cu levels were found significantly higher. However, Zn and Fe levels were found significantly lower in the patients group than those of controls. Cu levels were found tended to decrease, while Zn and Fe levels tended to increase during antimonial therapy. There was a negative correlation between serum Cu and Zn levels in CL patients (r = -0.322, p < 0.05). The findings showed that CL affects the essential trace element content and these changes began to disappear during antimonial therapy.
在40例皮肤利什曼病（CL）患者中，测定了CL感染对必需微量元素总含量的影响以及在锑剂治疗期间这些元素含量的变化，包括血清铁（Fe）、铜（Cu）和锌（Zn）。选取32名健康受试者作为对照组。患者组肌肉注射五价锑化合物（葡糖酸锑钠）（20mg/kg/天），持续三周。血清铜和锌水平通过火焰原子吸收光谱法测定，铁水平通过比色法测定。在锑剂治疗前，发现患者组铜水平显著较高。然而，患者组锌和铁水平显著低于对照组。在锑剂治疗期间，铜水平趋于下降，而锌和铁水平趋于上升。CL患者血清铜和锌水平之间存在负相关（r = -0.322，p < 0.05）。研究结果表明，CL会影响必需微量元素含量，且这些变化在锑剂治疗期间开始消失。
