van Heyningen R
Invest Ophthalmol Vis Sci. 1976 Sep;15(9):685-97.
I have discussed five aspects of lens metabolism and their possible relationship to cataract in man, and this has left me with five fundamental questions to be answered. 1. Are the fluorescent tryptophan derivatives, found only in the lens of man and higher primates, involved in the development of brown nuclear cataract? 2. Is naphthalene cataract in rabbits a model for any type of cataract in man--i.e., are quinones ever formed in the human eye? 3. Is diabetes the only cataract in which osmotic swelling is important? 4. Does self-digestion of protein in the human lens contribute to cataract development? 5. Are the consequences of the abnormal maturation of lens fibers, which occurs in tryptophan deficiency cataract in rats, ever seen in man?
我已经讨论了晶状体代谢的五个方面及其与人类白内障可能存在的关系，这使我有五个基本问题有待解答。1. 仅在人类和高等灵长类动物晶状体中发现的荧光色氨酸衍生物是否与棕色核性白内障的发生有关？2. 兔子的萘性白内障是否是人类任何类型白内障的模型——也就是说，醌是否曾在人眼中形成？3. 糖尿病是唯一一种渗透压肿胀起重要作用的白内障吗？4. 人晶状体中蛋白质的自我消化是否有助于白内障的发展？5. 在大鼠色氨酸缺乏性白内障中出现的晶状体纤维异常成熟的后果在人类中是否曾出现过？
