Takahashi T, Konishi H, Kozaki K, Osada H, Saji S, Takahashi T, Takahashi T
Laboratory of Ultrastructure Research, Gifu University School of Medicine, Tsukasamachi.
Jpn J Cancer Res. 1998 Apr;89(4):347-51. doi: 10.1111/j.1349-7006.1998.tb00569.x.
The chromosome region 17p13 is known to be frequently deleted in lung cancers. We recently showed the presence of an independent, commonly deleted region at 17p13.3, suggesting that in addition to p53 at 17p13.1 an as-yet-unidentified tumor suppressor gene may reside in this telomeric region. Interestingly, the chromosomal location of a recently isolated novel myc antagonist gene, termed ROX/Mnt, coincides exactly with the centromeric border of the commonly deleted region at 17p13.3 in lung cancers. In conjunction with the generally acknowledged roles of myc genes in the pathogenesis of lung cancers, these findings led us to investigate whether ROX/Mnt is altered in lung cancers. Despite an extensive search for alterations in 52 lung cancer specimens. somatic mutations of ROX/Mnt could not be identified. We conclude that ROX/Mnt itself is not a frequent target for 17p13.3 deletions in lung cancers and that further explorations are required to identify the putative tumor suppressor gene at 17p13.3.
已知17号染色体区域17p13在肺癌中经常发生缺失。我们最近发现17p13.3存在一个独立的、常见的缺失区域，这表明除了17p13.1处的p53基因外，该端粒区域可能还存在一个尚未鉴定的肿瘤抑制基因。有趣的是，最近分离出的一个名为ROX/Mnt的新型myc拮抗剂基因的染色体定位，恰好与肺癌中17p13.3常见缺失区域的着丝粒边界一致。结合myc基因在肺癌发病机制中普遍公认的作用，这些发现促使我们研究ROX/Mnt在肺癌中是否发生改变。尽管对52份肺癌标本进行了广泛的改变检测，但未发现ROX/Mnt的体细胞突变。我们得出结论，ROX/Mnt本身不是肺癌中17p13.3缺失的常见靶点，需要进一步探索以鉴定17p13.3处的假定肿瘤抑制基因。
