Moghal N E, Hulton S A, Milford D V
Department of Nephrology, Birmingham Children's Hospital, Ladywood, UK.
Clin Nephrol. 1998 May;49(5):293-5.
Ibuprofen is being widely used as an antipyretic in children. Recent studies indicate that it is as efficacious and with no significant difference in side-effects when compared to paracetamol. We describe three cases that illustrate that renal complications can occur when ibuprofen is prescribed in the presence of intravascular volume depletion and/or pre-existing renal problems. We discuss the mode of action of ibuprofen and recommend that its use as an antiypretic in children should be avoided in actual or potential intravascular volume contraction and in cases with pre-existing renal problems.
布洛芬作为一种退烧药在儿童中被广泛使用。最近的研究表明，与对乙酰氨基酚相比，它同样有效且副作用无显著差异。我们描述了三例病例，这些病例表明，在存在血管内容量耗竭和/或既往有肾脏问题的情况下使用布洛芬时，可能会发生肾脏并发症。我们讨论了布洛芬的作用方式，并建议在实际或潜在的血管内容量收缩以及既往有肾脏问题的情况下，应避免将其用作儿童退烧药。
