Grau O, Tuppin P, Slizewicz B, Launay V, Goujard C, Bahraoui E, Delfraissy J F, Montagnier L
Départment SIDA et Rétrovirus, Institut Pasteur, Paris, France.
AIDS Res Hum Retroviruses. 1998 May 20;14(8):661-7. doi: 10.1089/aid.1998.14.661.
We investigated the relationships between a putative cofactor of HIV infection, Mycoplasma penetrans, and the evolution of HIV disease. The evolution of titers of anti-M. penetrans antibodies in 58 randomly selected HIV-seropositive adult homosexual men was investigated. The median length of follow-up was 38 months. Thirty-six individuals was investigated. The median length of follow-up was 38 months. Thirty-six individuals (62.1%) remained M. penetrans seronegative (group 0). Fourteen patients (24.1%) had consistently low antibody titers or low antibody titer(s) in at least one sample and negative test(s) in the other(s). This pattern was possibly associated with latent or earlier infection (group 1). Eight patients (13.8%) had moderate to high antibody titers for long periods, indicating an active and persistent M. penetrans infection (group 2); four patients in this group presented a serological reactivation and thus probably developed an acute infection during the study; two had a stable and moderate level of antibody throughout the study; in two patients the antibody titers decreased substantially. Interestingly, CD4 cell counts declined more rapidly in group 2 than in group 0 (medians of -4.5 versus -2.1 cells/mm3/month, p < 0.05 and -0.16 versus 0 cell percentage/month, p < 0.05), whereas there was no significant difference between groups 1 and 0 (medians of -2.0 versus -2.1 cells/mm3/month and -0.15 versus 0 cell percentage/month). In patients with serological reactivation, the viral load was higher in sera with higher M. penetrans antibody titers. These findings suggest an association between active M. penetrans infection and progression of HIV disease.
我们研究了一种假定的HIV感染辅助因子——穿透支原体与HIV疾病进展之间的关系。对58名随机选取的HIV血清阳性成年男性同性恋者抗穿透支原体抗体滴度的变化情况进行了研究。随访时间中位数为38个月。对36名个体进行了研究。随访时间中位数为38个月。36名个体（62.1%）抗穿透支原体血清学检测仍为阴性（0组）。14名患者（24.1%）至少在一个样本中抗体滴度持续较低或滴度低，而在其他样本检测为阴性。这种模式可能与潜伏感染或早期感染有关（1组）。8名患者（13.8%）长期抗体滴度为中度至高度，表明存在活跃且持续的穿透支原体感染（2组）；该组中有4名患者出现血清学再激活，因此可能在研究期间发生了急性感染；2名患者在整个研究过程中抗体水平稳定且为中度；2名患者的抗体滴度大幅下降。有趣的是，2组患者的CD4细胞计数下降速度比0组更快（中位数分别为每月-4.5个细胞/mm³ 与 -2.1个细胞/mm³，p<0.05；每月-0.16%与0%，p<0.05），而1组和0组之间无显著差异（中位数分别为每月-2.0个细胞/mm³ 与 -2.1个细胞/mm³，以及每月-0.15%与0%）。在血清学再激活的患者中，穿透支原体抗体滴度较高的血清中病毒载量也较高。这些发现表明活跃的穿透支原体感染与HIV疾病进展之间存在关联。
