Blanchard A
Département du SIDA et des Retrovirus, Unité d'Oncologie Virale, Paris, France.
Wien Klin Wochenschr. 1997 Aug 8;109(14-15):590-3.
The persistence of HIV in the host is associated with a state of chronic immune activation with deleterious effects. In addition to HIV, several infectious agents can contribute to this activation and, consequently, to an increased HIV load. We have postulated that mycoplasmas could act as cofactors of HIV, contributing to a faster progression of the disease through increased immune activation. Mycoplasma penetrans was shown to be associated with HIV infection and recent data have indicated the capacity of this mycoplasma to activate different functions of the immune system. However, its role as an HIV cofactor remains to be demonstrated.
HIV在宿主体内的持续存在与具有有害影响的慢性免疫激活状态相关。除HIV外，几种感染因子可导致这种激活，进而导致HIV载量增加。我们推测支原体可能作为HIV的辅助因子，通过增强免疫激活促进疾病更快进展。穿透支原体已被证明与HIV感染有关，最近的数据表明这种支原体具有激活免疫系统不同功能的能力。然而，其作为HIV辅助因子的作用仍有待证实。
