Kroll S S, Robb G L, Reece G P, Miller M J, Evans G R, Baldwin B J, Wang B, Schusterman M A
Department of Plastic Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
J Reconstr Microsurg. 1998 May;14(4):263-8. doi: 10.1055/s-2007-1000179.
Answers to the question, "Does previous irradiation of a recipient site interfere with reconstruction by free-tissue transfer?" have been elusive. In an attempt to address that question, all free-flap procedures performed for reconstruction of the breast or of head and neck defects at the University of Texas M. D. Anderson Cancer Center between May 1, 1988 and February 15, 1996 were reviewed. The effects of prior irradiation of the recipient site on the incidence of total flap loss, partial flap loss, and thrombosis were assessed. During the study period, 1384 eligible free-flap reconstructions were performed. Total flap loss and partial flap loss were more common in the 428 flaps transferred to previously irradiated sites than in the patients without previous irradiation, but multiple logistic regression analysis showed that these differences were due to confounding factors. The authors conclude that previous irradiation of flap recipient sites does not statistically significantly affect the rate of partial or total free-flap loss.
对于“先前受区的放疗是否会干扰游离组织移植重建？”这一问题，一直没有明确答案。为了回答这个问题，我们回顾了1988年5月1日至1996年2月15日期间在德克萨斯大学MD安德森癌症中心进行的所有用于乳房重建或头颈部缺损重建的游离皮瓣手术。评估了先前受区放疗对皮瓣完全坏死、部分坏死及血栓形成发生率的影响。在研究期间，共进行了1384例符合条件的游离皮瓣重建手术。与未接受过先前放疗的患者相比，移植到先前接受过放疗部位的428例皮瓣中，皮瓣完全坏死和部分坏死更为常见，但多因素逻辑回归分析表明，这些差异是由混杂因素导致 的。作者得出结论，先前皮瓣受区的放疗对游离皮瓣部分或完全坏死率没有统计学上的显著影响。
