Lucarelli P, Corbo R M, Scacchi R, Palmarino R, Salsini G, Cristofori G, Osti L, Menini C, Vullo C, Bottini E
Am J Phys Anthropol. 1976 Sep;45(2):211-6. doi: 10.1002/ajpa.1330450208.
The present work reports a study of nine genetic polymorphic systems in the area of the Po Delta where malaria was endemic since the XIV century. Our data confirm some characteristics of this population already reported by other authors such as the high prevalence of thalassemia, the low prevalence of the rh (d) gene and the presence of G-6-PD deficiency. Among the other systems studied, i.e., AP, PGM1 ADA and AK, only AP frequencies of Po Delta population are significantly different from those of other continental Italian populations, the PC allele showing the lowest frequency so far observed.
本研究报告了对波河三角洲地区九个遗传多态系统的研究,自14世纪以来该地区疟疾流行。我们的数据证实了其他作者已经报道过的该人群的一些特征,如地中海贫血的高患病率、rh(d)基因的低患病率以及葡萄糖-6-磷酸脱氢酶(G-6-PD)缺乏症的存在。在所研究的其他系统中,即碱性磷酸酶(AP)、磷酸葡萄糖变位酶-1(PGM1)、腺苷脱氨酶(ADA)和腺苷酸激酶(AK),只有波河三角洲人群的AP频率与其他意大利大陆人群的频率有显著差异,PC等位基因的频率是迄今为止观察到的最低频率。