Isaksen C V, Eik-Nes S H, Blaas H G, Torp S H
Institute of Morphology, Trondheim University Hospital, Norway.
Ultrasound Obstet Gynecol. 1998 Apr;11(4):246-53. doi: 10.1046/j.1469-0705.1998.11040246.x.
Detection of fetal developmental abnormalities by ultrasound examination of pregnant women has become a specialized field of medicine. Quality control of this field requires detailed examination of aborted fetuses. In 408 fetuses and infants with developmental anomalies, the prenatal ultrasound findings were compared with the post-mortem findings. This study focused on 140 central nervous system (CNS) anomalies. Criteria for inclusion were an ultrasound examination at the National Center for Fetal Medicine (NCFM) and an autopsy performed during the period 1985-94. Results of the ultrasound and autopsy examinations were systematized into six different categories. Hydrocephaly and anencephaly were the most frequent abnormalities, together accounting for 50% of the CNS anomalies. In 20 cases (14%), the CNS anomalies were associated with other important anomalies or chromosomal aberrations. In 125 of the cases (89%), there was complete concordance between the ultrasound and autopsy diagnoses. Of the 15 CNS cases with discrepancies, seven had nearly complete concordance; if we include these, the correlation was 94%. In conclusion, this study confirms that developmental anomalies in the central nervous system are frequent and that ultrasound diagnoses are in good concordance with the autopsy diagnoses.
通过对孕妇进行超声检查来检测胎儿发育异常已成为医学的一个专业领域。该领域的质量控制需要对流产胎儿进行详细检查。在408例有发育异常的胎儿和婴儿中，将产前超声检查结果与尸检结果进行了比较。本研究聚焦于140例中枢神经系统（CNS）异常。纳入标准为在国家胎儿医学中心（NCFM）进行的超声检查以及在1985 - 1994年期间进行的尸检。超声和尸检检查结果被系统地分为六个不同类别。脑积水和无脑儿是最常见的异常，共占中枢神经系统异常的50%。在20例（14%）中，中枢神经系统异常与其他重要异常或染色体畸变相关。在125例（89%）中，超声和尸检诊断完全一致。在15例有差异的中枢神经系统病例中，7例几乎完全一致；如果将这些包括在内，相关性为94%。总之，本研究证实中枢神经系统发育异常很常见，且超声诊断与尸检诊断高度一致。
