Kira J, Kawano Y, Yamasaki K
Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Neurol Sci. 1998 May 7;157(2):138-42. doi: 10.1016/s0022-510x(98)00025-2.
The total and mite antigen-specific IgE in the sera were measured in 60 patients with multiple sclerosis (MS) and 40 healthy controls by an enzyme-linked immunosorbent assay using two common mite antigens, Dermatophagoides farinae and Dermatophagoides pteronyssinus, in order to study the role of atopy in MS. Neither the total IgE level nor the frequency of mite antigen-specific IgE differed significantly between the MS patients (mean total IgE 162 U/ml, 42% mite IgE-positive) and healthy controls (mean total IgE 168 U/ml, 35% mite IgE-positive). The MS patients with mite antigen-specific IgE showed a significantly higher level of serum total IgE (mean 293 U/ml, P=0.0005) and a higher frequency of atopic disorders (36%, P=0.0508) than did the MS patients without mite antigen-specific IgE (mean total IgE 68 U/ml, atopic disorders 14%). The former group also showed a significantly higher frequency of male (P=0.0216), a younger age of onset (P=0.0081), a lower expanded disability status scale (EDSS) score (P=0.03) and a lower protein content in the cerebrospinal fluid (CSF) (P=0.0426) than the latter, while the duration of disease and a number of relapses did not differ significantly between the two groups. In addition, the mite IgE-positive MS showed a very low frequency of oligoclonal IgG bands in CSF (4%) and a significantly higher association of HLA-A24 (87.5%) than the healthy controls (45%). Therefore, the presence of IgE response to the mite antigens and atopy appeared to significantly lessen the severity of the disease and the immunologic abnormalities in MS.
为了研究特应性在多发性硬化症（MS）中的作用，采用酶联免疫吸附测定法，使用两种常见的螨抗原（粉尘螨和屋尘螨），对60例多发性硬化症患者和40名健康对照者血清中的总IgE和螨抗原特异性IgE进行了检测。MS患者（平均总IgE 162 U/ml，42%螨IgE阳性）和健康对照者（平均总IgE 168 U/ml，35%螨IgE阳性）之间的总IgE水平和螨抗原特异性IgE频率均无显著差异。与无螨抗原特异性IgE的MS患者（平均总IgE 68 U/ml，特应性疾病14%）相比，有螨抗原特异性IgE的MS患者血清总IgE水平显著更高（平均293 U/ml，P = 0.0005），特应性疾病频率更高（36%，P = 0.0508）。前一组男性频率也显著更高（P = 0.0216），发病年龄更年轻（P = 0.0081），扩展残疾状态量表（EDSS）评分更低（P = 0.03），脑脊液（CSF）中的蛋白质含量更低（P = 0.0426），而两组之间的病程和复发次数无显著差异。此外，螨IgE阳性的MS患者脑脊液中寡克隆IgG带的频率非常低（4%），且与HLA - A24的关联显著高于健康对照者（45%）。因此，对螨抗原的IgE反应和特应性的存在似乎显著减轻了MS疾病的严重程度和免疫异常。
