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1
Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family.人类MUC5AC粘蛋白基因3'区域的基因组组织：11p15.5粘蛋白基因家族存在共同祖先基因的更多证据。
Biochem J. 1998 Jun 15;332 ( Pt 3)(Pt 3):729-38. doi: 10.1042/bj3320729.
2
Evolutionary history of the 11p15 human mucin gene family.人类11p15粘蛋白基因家族的进化史。
J Mol Evol. 1998 Jan;46(1):102-6. doi: 10.1007/pl00006276.
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Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region.人类黏蛋白基因MUC5AC：其5'区域和中央重复区域的结构
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Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.上皮癌细胞中11p15粘蛋白基因（MUC2、MUC5AC、MUC5B、MUC6）的表观遗传调控（DNA甲基化、组蛋白修饰）
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Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?人类黏蛋白基因MUC5AC的特征：11p15黏蛋白基因富含半胱氨酸的共有结构域？
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Genomic organization of the 3' region of the human mucin gene MUC5B.人类黏蛋白基因MUC5B 3'区域的基因组结构
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本文引用的文献

1
Evolutionary history of the 11p15 human mucin gene family.人类11p15粘蛋白基因家族的进化史。
J Mol Evol. 1998 Jan;46(1):102-6. doi: 10.1007/pl00006276.
2
Genomic organization of the 3' region of the human mucin gene MUC5B.人类黏蛋白基因MUC5B 3'区域的基因组结构
J Biol Chem. 1997 Jul 4;272(27):16873-83. doi: 10.1074/jbc.272.27.16873.
3
The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis Of the primary amino acid sequence.人分泌性粘蛋白MUC6的羧基末端序列。一级氨基酸序列分析。
J Biol Chem. 1997 Jun 27;272(26):16398-403. doi: 10.1074/jbc.272.26.16398.
4
Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus.人类黏蛋白基因（MUC8）的染色体定位及对应羧基末端的cDNA克隆。
Am J Respir Cell Mol Biol. 1997 Mar;16(3):232-41. doi: 10.1165/ajrcmb.16.3.9070607.
5
Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus.人类肠道粘蛋白基因（MUC2）位点的组织和调控方面
J Biol Chem. 1997 Mar 21;272(12):7968-76. doi: 10.1074/jbc.272.12.7968.
6
Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family.人类粘蛋白基因MUC5B，10.7kb的大型中央外显子编码各种交替的亚结构域，形成一个超级重复序列。11p15.5基因家族的结构证据。
J Biol Chem. 1997 Feb 7;272(6):3168-78. doi: 10.1074/jbc.272.6.3168.
7
Human mucin genes assigned to 11p15.5: identification and organization of a cluster of genes.定位于11p15.5的人类黏蛋白基因：一组基因的鉴定与组织
Genomics. 1996 Dec 15;38(3):340-52. doi: 10.1006/geno.1996.0637.
8
Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains.人胃粘蛋白cDNA的克隆与分析揭示了两种类型的保守富含半胱氨酸结构域。
Biochem J. 1995 Jun 15;308 ( Pt 3)(Pt 3):831-8. doi: 10.1042/bj3080831.
9
Identification of a 42-kDa nuclear factor (NF1-MUC5B) from HT-29 MTX cells that binds to the 3' region of human mucin gene MUC5B.从HT-29 MTX细胞中鉴定出一种与人类粘蛋白基因MUC5B的3'区域结合的42 kDa核因子（NF1-MUC5B）。
Biochem Biophys Res Commun. 1996 Mar 7;220(1):186-91. doi: 10.1006/bbrc.1996.0378.
10
Aberrant expression of a human mucin gene (MUC5AC) in rectosigmoid villous adenoma.人黏蛋白基因（MUC5AC）在直肠乙状结肠绒毛状腺瘤中的异常表达。
Gastroenterology. 1996 Jan;110(1):84-91. doi: 10.1053/gast.1996.v110.pm8536891.

人类MUC5AC粘蛋白基因3'区域的基因组组织：11p15.5粘蛋白基因家族存在共同祖先基因的更多证据。

Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family.

作者信息

Buisine M P, Desseyn J L, Porchet N, Degand P, Laine A, Aubert J P

机构信息

INSERM Unité 377, Place de Verdun, 59045 Lille Cedex, France.

出版信息

Biochem J. 1998 Jun 15;332 ( Pt 3)(Pt 3):729-38. doi: 10.1042/bj3320729.

DOI:10.1042/bj3320729
PMID:9620876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1219534/
Abstract

The human mucin gene MUC5AC is mapped clustered with MUC2, MUC5B and MUC6 on chromosome 11p15.5. We report here the isolation and characterization of a genomic cosmid clone, designated ELO9, spanning the 3'-region of MUC5AC and the 5'-region of MUC5B, allowing us to conclude that MUC5AC and MUC5B have the same transcriptional orientation. We determined the genomic organization and the entire sequence of the 3'-region of MUC5AC. The comparative molecular analysis of MUC5AC and MUC5B points to a remarkable similarity in the size and the distribution of exons, and in the type of splice sites, supporting the notion that MUC5AC and MUC5B have evolved from a single common ancestral gene. The derivation of the four genes of the 11p15.5 mucin gene family from a single ancestral gene is discussed.

摘要

人类黏蛋白基因MUC5AC定位于11号染色体p15.5上，与MUC2、MUC5B和MUC6成簇排列。我们在此报告一个基因组黏粒克隆ELO9的分离和特性，该克隆跨越MUC5AC的3'区域和MUC5B的5'区域，使我们能够得出MUC5AC和MUC5B具有相同转录方向的结论。我们确定了MUC5AC 3'区域的基因组结构和完整序列。MUC5AC和MUC5B的比较分子分析表明，外显子的大小和分布以及剪接位点类型具有显著相似性，支持MUC5AC和MUC5B是从单一共同祖先基因进化而来的观点。本文讨论了11p15.5黏蛋白基因家族的四个基因从单一祖先基因的衍生情况。