人类MUC5AC粘蛋白基因3'区域的基因组组织：11p15.5粘蛋白基因家族存在共同祖先基因的更多证据。
Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family.
作者信息
Buisine M P, Desseyn J L, Porchet N, Degand P, Laine A, Aubert J P
机构信息
INSERM Unité 377, Place de Verdun, 59045 Lille Cedex, France.
出版信息
Biochem J. 1998 Jun 15;332 ( Pt 3)(Pt 3):729-38. doi: 10.1042/bj3320729.
Abstract
The human mucin gene MUC5AC is mapped clustered with MUC2, MUC5B and MUC6 on chromosome 11p15.5. We report here the isolation and characterization of a genomic cosmid clone, designated ELO9, spanning the 3'-region of MUC5AC and the 5'-region of MUC5B, allowing us to conclude that MUC5AC and MUC5B have the same transcriptional orientation. We determined the genomic organization and the entire sequence of the 3'-region of MUC5AC. The comparative molecular analysis of MUC5AC and MUC5B points to a remarkable similarity in the size and the distribution of exons, and in the type of splice sites, supporting the notion that MUC5AC and MUC5B have evolved from a single common ancestral gene. The derivation of the four genes of the 11p15.5 mucin gene family from a single ancestral gene is discussed.
摘要
人类黏蛋白基因MUC5AC定位于11号染色体p15.5上，与MUC2、MUC5B和MUC6成簇排列。我们在此报告一个基因组黏粒克隆ELO9的分离和特性，该克隆跨越MUC5AC的3'区域和MUC5B的5'区域，使我们能够得出MUC5AC和MUC5B具有相同转录方向的结论。我们确定了MUC5AC 3'区域的基因组结构和完整序列。MUC5AC和MUC5B的比较分子分析表明，外显子的大小和分布以及剪接位点类型具有显著相似性，支持MUC5AC和MUC5B是从单一共同祖先基因进化而来的观点。本文讨论了11p15.5黏蛋白基因家族的四个基因从单一祖先基因的衍生情况。
相似文献
1
Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family.人类MUC5AC粘蛋白基因3'区域的基因组组织：11p15.5粘蛋白基因家族存在共同祖先基因的更多证据。
Biochem J. 1998 Jun 15;332 ( Pt 3)(Pt 3):729-38. doi: 10.1042/bj3320729.
2
Evolutionary history of the 11p15 human mucin gene family.人类11p15粘蛋白基因家族的进化史。
J Mol Evol. 1998 Jan;46(1):102-6. doi: 10.1007/pl00006276.
3
Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region.人类黏蛋白基因MUC5AC：其5'区域和中央重复区域的结构
Biochem J. 2001 Sep 15;358(Pt 3):763-72. doi: 10.1042/0264-6021:3580763.
4
The mouse secreted gel-forming mucin gene cluster.小鼠分泌凝胶形成黏蛋白基因簇。
Biochim Biophys Acta. 2004 Feb 20;1676(3):240-50. doi: 10.1016/j.bbaexp.2004.01.001.
5
Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.上皮癌细胞中11p15粘蛋白基因（MUC2、MUC5AC、MUC5B、MUC6）的表观遗传调控（DNA甲基化、组蛋白修饰）
Oncogene. 2007 Oct 4;26(45):6566-76. doi: 10.1038/sj.onc.1210479. Epub 2007 Apr 30.
6
Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?人类黏蛋白基因MUC5AC的特征：11p15黏蛋白基因富含半胱氨酸的共有结构域？
Biochem J. 1995 Jan 1;305 ( Pt 1)(Pt 1):211-9. doi: 10.1042/bj3050211.
7
Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon.人类黏蛋白基因MUC5B的基因组结构。大的中央外显子上游的cDNA和基因组序列。
J Biol Chem. 1998 Nov 13;273(46):30157-64. doi: 10.1074/jbc.273.46.30157.
8
Genomic organization of the 3' region of the human mucin gene MUC5B.人类黏蛋白基因MUC5B 3'区域的基因组结构
J Biol Chem. 1997 Jul 4;272(27):16873-83. doi: 10.1074/jbc.272.27.16873.
9
The oligomerization of a family of four genetically clustered human gastrointestinal mucins.一类四种基因聚集的人类胃肠道粘蛋白的寡聚化
Glycobiology. 1998 Jan;8(1):67-75. doi: 10.1093/glycob/8.1.67.
10
Differential expression of the chromosome 11 mucin genes in colorectal cancer.11号染色体黏蛋白基因在结直肠癌中的差异表达。
J Pathol. 2001 Oct;195(3):327-35. doi: 10.1002/path.951.
引用本文的文献
1
Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B.黏蛋白 MUC5AC N 端区域的组装和组织：与 MUC5B 在结构和功能上区别的指示。
Proc Natl Acad Sci U S A. 2021 Sep 28;118(39). doi: 10.1073/pnas.2104490118.
2
Muc5b-deficient mice develop early histological lung abnormalities.Muc5b基因缺陷型小鼠出现早期组织学肺部异常。
Biol Open. 2019 Nov 7;8(11):bio046359. doi: 10.1242/bio.046359.
3
Ramifications of secreted mucin MUC5AC in malignant journey: a holistic view.分泌黏蛋白 MUC5AC 在恶性进展中的影响：整体观点。
Carcinogenesis. 2018 May 3;39(5):633-651. doi: 10.1093/carcin/bgy019.
4
Muc5ac mucin expression during rat skin development.大鼠皮肤发育过程中的Muc5ac黏蛋白表达。
Eur J Histochem. 2015 Feb 20;59(1):2462. doi: 10.4081/ejh.2015.2462.
5
The gastrointestinal mucus system in health and disease.健康与疾病中的胃肠道黏液系统。
Nat Rev Gastroenterol Hepatol. 2013 Jun;10(6):352-61. doi: 10.1038/nrgastro.2013.35. Epub 2013 Mar 12.
6
Mapping the protein domain structures of the respiratory mucins: a mucin proteome coverage study.绘制呼吸道黏蛋白的蛋白结构域图谱：黏蛋白蛋白质组覆盖度研究。
J Proteome Res. 2012 Aug 3;11(8):4013-23. doi: 10.1021/pr300058z. Epub 2012 Jun 28.
7
Mass spectrometric analysis of mucin core proteins.黏蛋白核心蛋白的质谱分析
Methods Mol Biol. 2012;842:67-79. doi: 10.1007/978-1-61779-513-8_4.
8
Extensive lineage-specific gene duplication and evolution of the spiggin multi-gene family in stickleback.棘鱼中spiggin多基因家族广泛的谱系特异性基因复制与进化。
BMC Evol Biol. 2007 Nov 4;7:209. doi: 10.1186/1471-2148-7-209.
9
Regulation of airway mucin gene expression.气道黏蛋白基因表达的调控
Annu Rev Physiol. 2008;70:405-29. doi: 10.1146/annurev.physiol.70.113006.100441.
10
Mucin granule intraluminal organization.黏蛋白颗粒腔内组织
Am J Respir Cell Mol Biol. 2007 Feb;36(2):183-90. doi: 10.1165/rcmb.2006-0291TR. Epub 2006 Sep 7.
本文引用的文献
1
Evolutionary history of the 11p15 human mucin gene family.人类11p15粘蛋白基因家族的进化史。
J Mol Evol. 1998 Jan;46(1):102-6. doi: 10.1007/pl00006276.
2
Genomic organization of the 3' region of the human mucin gene MUC5B.人类黏蛋白基因MUC5B 3'区域的基因组结构
J Biol Chem. 1997 Jul 4;272(27):16873-83. doi: 10.1074/jbc.272.27.16873.
3
The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis Of the primary amino acid sequence.人分泌性粘蛋白MUC6的羧基末端序列。一级氨基酸序列分析。
J Biol Chem. 1997 Jun 27;272(26):16398-403. doi: 10.1074/jbc.272.26.16398.
4
Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus.人类黏蛋白基因（MUC8）的染色体定位及对应羧基末端的cDNA克隆。
Am J Respir Cell Mol Biol. 1997 Mar;16(3):232-41. doi: 10.1165/ajrcmb.16.3.9070607.
5
Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus.人类肠道粘蛋白基因（MUC2）位点的组织和调控方面
J Biol Chem. 1997 Mar 21;272(12):7968-76. doi: 10.1074/jbc.272.12.7968.
6
Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family.人类粘蛋白基因MUC5B，10.7kb的大型中央外显子编码各种交替的亚结构域，形成一个超级重复序列。11p15.5基因家族的结构证据。
J Biol Chem. 1997 Feb 7;272(6):3168-78. doi: 10.1074/jbc.272.6.3168.
7
Human mucin genes assigned to 11p15.5: identification and organization of a cluster of genes.定位于11p15.5的人类黏蛋白基因：一组基因的鉴定与组织
Genomics. 1996 Dec 15;38(3):340-52. doi: 10.1006/geno.1996.0637.
8
Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains.人胃粘蛋白cDNA的克隆与分析揭示了两种类型的保守富含半胱氨酸结构域。
Biochem J. 1995 Jun 15;308 ( Pt 3)(Pt 3):831-8. doi: 10.1042/bj3080831.
9
Identification of a 42-kDa nuclear factor (NF1-MUC5B) from HT-29 MTX cells that binds to the 3' region of human mucin gene MUC5B.从HT-29 MTX细胞中鉴定出一种与人类粘蛋白基因MUC5B的3'区域结合的42 kDa核因子（NF1-MUC5B）。
Biochem Biophys Res Commun. 1996 Mar 7;220(1):186-91. doi: 10.1006/bbrc.1996.0378.
10
Aberrant expression of a human mucin gene (MUC5AC) in rectosigmoid villous adenoma.人黏蛋白基因（MUC5AC）在直肠乙状结肠绒毛状腺瘤中的异常表达。
Gastroenterology. 1996 Jan;110(1):84-91. doi: 10.1053/gast.1996.v110.pm8536891.
Zotero 插件