Rinaldo C H, Traavik T, Hey A
Department of Virology, Institute of Medical Biology, University of Tromso, N-9037 Tromso, Norway.
J Virol. 1998 Jul;72(7):6233-6. doi: 10.1128/JVI.72.7.6233-6236.1998.
Primate polyomavirus genomes all contain an open reading frame at the 5' end of the late coding region called the agnogene. A simian virus 40 agnoprotein with unknown functions has previously been demonstrated. We now show that a BK virus agnoprotein appears in the perinuclear area and cytoplasm late in the infectious cycle. It is phosphorylated in vivo and coimmunoprecipitates with a subset of host cell proteins.
灵长类多瘤病毒基因组在晚期编码区的5'端均含有一个名为agnogene的开放阅读框。此前已证实猿猴病毒40的agnoprotein功能未知。我们现在发现，BK病毒的agnoprotein在感染周期后期出现在核周区域和细胞质中。它在体内被磷酸化，并与一部分宿主细胞蛋白发生共免疫沉淀。
