Casasnovas J M, Bickford J K, Springer T A
The Center for Blood Research and Harvard Medical School Department of Pathology, Boston, Massachusetts 02115, USA.
J Virol. 1998 Jul;72(7):6244-6. doi: 10.1128/JVI.72.7.6244-6246.1998.
Fragments of intercellular adhesion molecule 1 (ICAM- 1) containing only the two most N terminal of its five immunoglobulin SF domains bind to rhinovirus 3 with the same affinity and kinetics as a fragment with the entire extracellular domain. The fully active two-domain fragments contain 5 or 14 more residues than a previously described fragment that is only partially active. Comparison of X-ray crystal structures show differences at the bottom of domain 2. Four different glycoforms of ICAM- 1 bind with identical kinetics.
仅包含其五个免疫球蛋白超家族(SF)结构域中最靠近N端的两个结构域的细胞间粘附分子1(ICAM-1)片段,与鼻病毒3的结合亲和力和动力学与具有完整细胞外结构域的片段相同。完全活性的双结构域片段比先前描述的仅部分活性的片段多5个或14个残基。X射线晶体结构比较显示结构域2底部存在差异。ICAM-1的四种不同糖型以相同的动力学结合。