Michalak K, Austin C, Diesel S, Bacon M J, Zimmerman P, Maslow J N
McHenry County Department of Health, Woodstock, Illinois 60098, USA.
Emerg Infect Dis. 1998 Apr-Jun;4(2):283-7. doi: 10.3201/eid0402.980217.
Between 1994 and 1996, three elephants from an exotic animal farm in Illinois died of pulmonary disease due to Mycobacterium tuberculosis. In October 1996, a fourth living elephant was culture-positive for M. tuberculosis. Twenty-two handlers at the farm were screened for tuberculosis (TB); eleven had positive reactions to intradermal injection with purified protein derivative. One had smear-negative, culture-positive active TB. DNA fingerprint comparison by IS6110 and TBN12 typing showed that the isolates from the four elephants and the handler with active TB were the same strain. This investigation indicates transmission of M. tuberculosis between humans and elephants.
1994年至1996年间，伊利诺伊州一家外来动物养殖场的三头大象死于由结核分枝杆菌引起的肺部疾病。1996年10月，第四头存活的大象结核分枝杆菌培养呈阳性。对该养殖场的22名饲养员进行了结核病筛查；11人对皮内注射纯化蛋白衍生物呈阳性反应。其中一人涂片阴性、培养阳性，患有活动性结核病。通过IS6110和TBN12分型进行的DNA指纹比较显示，来自四头大象和患有活动性结核病的饲养员的分离株是同一菌株。这项调查表明结核分枝杆菌在人和大象之间传播。
