Belli S, Bruno C, Comba P, Grignoli M
Laboratorio di Igiene Ambientale, Istituto Superiore di Sanità, Roma.
Epidemiol Prev. 1998 Jan-Mar;22(1):8-11.
The cause-specific mortality of 233 asbestos cement workers employed by the Fibronit company in Bari and compensated for asbestosis was investigated. Cohort members were enrolled on 31.12.1979 and followed through 30.4.1997; follow-up was completed for 98.3% of study subjects, and causes of death were ascertained for 96.6% of deceased subjects. Observed mortality was contrasted to that expected according to cause-sex-age- and calendar time-specific rates of the population resident in the Apulia Region. All causes observed mortality exceeded expected value (SMR: 117, 87 observed), due to a significant' increase in pneumoconiosis (SMR: 11238, 14 observed) and malignant neoplasms (SMR: 163, 38 observed)). A significant decrease of circulatory diseases was found (SMR: 64, 18 observed). Among cancer deaths, the following sites showed a significant excess: lung (SMR: 206, 17 observed), pleura (SMR: 2551, 4 observed), mediastinum (SMR: 2367, 2 observed) and peritoneum (SMR: 2877, 2 observed). The excess mortality due to asbestosis, respiratory cancer and peritoned neoplasms can be causally attributed to occupational asbestos exposure.
对巴里市菲布罗尼特公司雇佣的233名石棉水泥工人的特定病因死亡率进行了调查,这些工人均患有石棉肺并已获得赔偿。队列成员于1979年12月31日登记入组,并随访至1997年4月30日;98.3%的研究对象完成了随访,96.6%的死亡对象死因得以确定。将观察到的死亡率与根据普利亚地区常住居民的病因、性别、年龄和日历时间特定率所预期的死亡率进行对比。观察到的所有病因死亡率均超过预期值(标准化死亡比:117,观察到87例),这是由于尘肺病(标准化死亡比:11238,观察到14例)和恶性肿瘤(标准化死亡比:163,观察到38例)显著增加所致。发现循环系统疾病死亡率显著下降(标准化死亡比:64,观察到18例)。在癌症死亡病例中,以下部位显示出显著超额:肺(标准化死亡比:206,观察到17例)、胸膜(标准化死亡比:2551,观察到4例)、纵隔(标准化死亡比:2367,观察到2例)和腹膜(标准化死亡比:2877,观察到2例)。石棉肺、呼吸道癌症和腹膜肿瘤导致超额死亡可归因于职业性石棉暴露。