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[切尔诺贝利核电站事故受害者十二指肠消化性溃疡的病理形态学特征:胃黏膜的变化]

[The pathomorphological characteristics of duodenal peptic ulcer in the victims of the accident at the Chernobyl Atomic Electric Power Station: changes in the gastric mucosa].

作者信息

Degtiareva L V, Moroz G Z

出版信息

Lik Sprava. 1998 Jan-Feb(1):13-6.

PMID:9621605
Abstract

Gastrobiopsies were studied from patients with duodenal ulcer, 62 of whom took part in the elimination of the effects of the Chernobyl Nuclear Power Plant breakdown, 33 were permanent residents in the territories affected by radioactive contamination, and 36 formed the control group. Several distinguishing features were noted in chronic Helicobacter gastritis in victims of Chernobyl accident versus control, such as higher degree and activity of the inflammatory process spreading over large tissue areas, with Helicobacter pylori being recordable in the gastric mucosa in highly increased numbers, and more frequent occurrence of atrophic changes. Incorporation of radionuclides and external irradiation at dose levels exceeding 25 cause most significant disturbances in regeneration of epithelium, with its enterolyzation and dysplasia going on, which fact makes the risk of neoplastic transformations higher.

摘要

对十二指肠溃疡患者的胃活检样本进行了研究,其中62人参与了切尔诺贝利核电站事故影响消除工作,33人是受放射性污染地区的常住居民,36人组成了对照组。与对照组相比,切尔诺贝利事故受害者的慢性幽门螺杆菌胃炎有几个显著特征,如炎症过程的程度和活动度更高,扩散到大面积组织区域,胃黏膜中可记录到数量大幅增加的幽门螺杆菌,以及萎缩性改变更频繁发生。摄入放射性核素和超过25剂量水平的外部照射会对上皮再生造成最严重的干扰,随之出现肠化生和发育异常,这一事实使得肿瘤转化的风险更高。

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