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[切尔诺贝利核电站事故受害者十二指肠消化性溃疡的病理形态学特征:缺损外十二指肠黏膜的变化]

[The pathomorphological characteristics of duodenal peptic ulcer in the victims of the accident at the Chernobyl Atomic Electric Power Station: changes in the duodenal mucosa outside of the defect].

作者信息

Degtiareva L V, Moroz G Z

出版信息

Lik Sprava. 1998 Jan-Feb(1):16-8.

PMID:9621606
Abstract

A study was made of duodenobiopsies from patients with duodenal ulcer, 62 of whom took part in the elimination of the effects of the Chernobyl Nuclear Power Plant accident, 33 have been resident in the territories affected by radioactive contamination, and 36 were a group of nosological control. In the ChNPP accident victims, the inflammatory process in chronic duodenitis tended to be more pronounced and active, with the atrophic changes in the mucous membrane being more commonly seen. Incorporation of radionuclides and external irradiation in a dose exceeding 25 sGy causes most profound disturbances in regeneration of epithelium entailing metaplasia and dysplasia of gastric epithelium in duodenum, which facts heighten the risk for neoplasmogenesis.

摘要

对十二指肠溃疡患者的十二指肠活检进行了研究,其中62人参与了切尔诺贝利核电站事故影响消除工作,33人居住在受放射性污染地区,36人作为疾病对照群体。在切尔诺贝利核电站事故受害者中,慢性十二指肠炎症过程往往更明显且活跃,黏膜萎缩性改变更常见。放射性核素的摄入和超过25 sGy的外照射会导致上皮再生出现最严重的紊乱,进而引起十二指肠胃上皮化生和发育异常,这些情况增加了肿瘤发生的风险。

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