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[切尔诺贝利事故清理者十二指肠溃疡患者胃和十二指肠黏膜分泌结构的形态功能特征]

[Morphofunctional characteristics of secretion-producing structures of the gastric and duodenal mucosa in liquidators of aftermaths of the Chernobyl accident with peptic ulcer of the duodenum].

作者信息

Dehtiar'ova L V, Kozlova T H

出版信息

Lik Sprava. 2001 Jan-Feb(1):19-23.

PMID:15311684
Abstract

With the aid of the comparative structural analysis of 145 biopsy specimens of the gastric and duodenal mucosa obtained from two groups of patients with peptic ulcer of the duodenum (liquidators of effects of the Chernobyl power plant accident and those subjects comprizing the control group), particular morphological features were revealed in the liquidators. These included the following: significant decline in parameters for parietal cells (mostly nuclei), striking alterable changes in their cytoplasma; transformation of the process of glycosylation of glycoproteins in the course of mucus production with disturbances of formation, excertion of the secretion and cytoprotective properties of the mucus; increase in the proliferative activity of the epithelium with insufficiency of cytodifferentiation and functional inadequacy.

摘要

通过对两组十二指肠溃疡患者(切尔诺贝利核电站事故影响清理者和对照组受试者)的145份胃和十二指肠黏膜活检标本进行比较结构分析,发现清理者具有特定的形态学特征。这些特征包括:壁细胞参数(主要是细胞核)显著下降,其细胞质出现明显的可变变化;黏液产生过程中糖蛋白糖基化过程发生改变,伴有黏液形成、分泌及细胞保护特性的紊乱;上皮细胞增殖活性增加,伴有细胞分化不足和功能不全。

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