Leidl W, Bentley M I, Gass G H
Andrologia. 1976;8(2):131-6. doi: 10.1111/j.1439-0272.1976.tb02121.x.
New born Sprague Dawley rats were injected daily either with 50 (n=8), 100 (9) or 200 (10) mug FSH; with 50 (9), 100 (5), 200 (10) mug LH; with a combination of 50 mug FSH + 50 mug LH (10); or with the vehicle 0.9% saline (10). The animals were sacrificied at an age of 16 days. There was no influence of the hormones on the body weight. FSH caused a dose dependant stimulation of the testes growth (163, 186, 227 mg for the 50, 100 and 200 mug group; control 139 mg; diff. to control P less than or equal to 0.05, 0.01, and 0.01), whereas LH had no effect (123, 154 and 133 mg for the 50, 100 and 200 mug. LH group). The weight of the seminal vesicles was increased slightly by LH only (Diff. to control P less than 0l01). The serum androgen level was not changed by any of the treatments. The stage of the spermatogenesis was not altered by the hormones. There was no significant difference in the diameter of the seminiferous tubules. The higher testes weight after FSH administration was caused by an increase of length of the seminiferous tubules (25 m, 30 m and 35 m for 50 mug, 100 mug, and 200 mug FSH; control 23 m; diff.: P less than or equal to 0.05, less than or equal to 0.01, less than or equal to 0.01). The conclusion is that FSH has a specific effect on the longitudinal growth of the seminiferous tubules in prepubertal rats.
给新生的斯普拉格-道利大鼠每日注射50微克（n = 8）、100微克（9只）或200微克（10只）促卵泡激素（FSH）；50微克（9只）、100微克（5只）、200微克（10只）促黄体生成素（LH）；50微克FSH + 50微克LH的组合（10只）；或注射溶媒0.9%生理盐水（10只）。在动物16日龄时将其处死。激素对体重没有影响。FSH引起睾丸生长的剂量依赖性刺激（50微克、100微克和200微克组的睾丸重量分别为163毫克、186毫克和227毫克；对照组为139毫克；与对照组相比差异：P≤0.05、0.01和0.01），而LH没有作用（50微克、100微克和200微克LH组的睾丸重量分别为123毫克、154毫克和133毫克）。仅LH使精囊重量略有增加（与对照组相比差异：P＜0.01）。任何一种处理均未改变血清雄激素水平。激素未改变精子发生阶段。生精小管直径没有显著差异。给予FSH后睾丸重量增加是由于生精小管长度增加所致（50微克、100微克和200微克FSH组的生精小管长度分别为25微米、30微米和35微米；对照组为23微米；差异：P≤0.05、≤0.01、≤0.01）。结论是FSH对青春期前大鼠生精小管的纵向生长有特异性作用。
