Hooten W M, Lyketsos C G
Department of Internal Medicine, Mayo Graduate School of Medicine, Rochester, Minn, USA.
Dement Geriatr Cogn Disord. 1998 May-Jun;9(3):164-74. doi: 10.1159/000017042.
Alzheimer's disease and frontotemporal dementia are two of the most common types of degenerative dementia. In conjunction with a complete neuropsychiatric examination, the Executive Interview, Mini-Mental State Exam, Alzheimer's Disease Scale, Pick's Disease Scale and the Informant-Based Questionnaire have been used to distinguish between these two disorders on clinical grounds. In a review of two studies, scores from these rating scales are subjected to receiver operator characteristic curve analysis to determine the cut-off value for each scale which yields the highest sensitivity and specificity with regard to differentiating between Alzheimer's disease and frontotemporal dementia. Finally, the Informant-Based Questionnaire is discussed and compared to each rating scale to demonstrate the important features and limitations of each.
阿尔茨海默病和额颞叶痴呆是最常见的两种退行性痴呆类型。结合全面的神经精神检查，执行访谈、简易精神状态检查、阿尔茨海默病量表、匹克病量表和基于 informant 的问卷已被用于从临床角度区分这两种疾病。在对两项研究的综述中，对这些评分量表的分数进行接受者操作特征曲线分析，以确定每个量表的临界值，该临界值在区分阿尔茨海默病和额颞叶痴呆方面具有最高的敏感性和特异性。最后，对基于 informant 的问卷进行了讨论，并与每个评分量表进行了比较，以展示每个量表的重要特征和局限性。
