Campbell J M, Gilmore D P, Russell D, Growney C A, Favor G, Weir J, Stone T W, Payne A P
Institute of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, University of Glasgow, UK.
Neuroscience. 1998 Jul;85(2):323-5. doi: 10.1016/s0306-4522(98)00053-0.
The AS/AGU rat is a mutant derived from the Albino Swiss (AS) strain. It is characterized by an ungainly, staggering gait, hind limb rigidity, whole body tremor and, in older animals, difficulty in initiating movement. As and AS/AGU males aged three, six and nine months (n=6 per group) were used to estimate the levels of dopamine and its metabolites in the extracellular fluid of the caudate-putamen. The results indicate a profound loss of dopamine in the extracellular fluid at all age points examined, together with an increase in the concentration of the metabolite 3,4-dihydroxyphenylacetic acid. It is suggested that these changes reflect a defect of dopaminergic neuron function which may underlie the motor disorder seen in these animals.
AS/AGU大鼠是一种源自白化瑞士（AS）品系的突变体。其特征为步态笨拙、蹒跚，后肢僵硬，全身震颤，且在老龄动物中存在运动启动困难。选用3个月、6个月和9个月龄的AS和AS/AGU雄性大鼠（每组n = 6）来估计尾状核-壳核细胞外液中多巴胺及其代谢产物的水平。结果表明，在所检测的所有年龄点，细胞外液中的多巴胺均显著减少，同时代谢产物3,4-二羟基苯乙酸的浓度增加。提示这些变化反映了多巴胺能神经元功能缺陷，这可能是这些动物出现运动障碍的基础。
