Helling K, Loddenkemper C, Scherer H
Universitäts-HNO-Klinik, Klinikum Benjamin Franklin, Freien Universität Berlin.
HNO. 2003 Dec;51(12):993-7. doi: 10.1007/s00106-003-0811-4. Epub 2003 Apr 8.
Basaloid squamous cell carcinoma s a rare, highly malignant carcinoma variant typically situated in the tongue base, supraglottis and pyriform sinus. It is usually only diagnosed at a very advanced stage due to its tendency towards submucosal growth, deep infiltration and early local and distant metastases.
PATIENTS/METHODS: The case described involves a 39-year-old man with the clinical and histopathological findings typical for this neoplasm.
In contrast to simple squamous cell carcinomas, the basaloid variant with its very poor prognosis calls for therapeutic decisions that give particular consideration to quality of life. It should be stressed that highly invasive surgery is justified only in exceptional cases because of the high local recurrence rate and early distant metastases.
The case presented shows that radio- and chemotherapeutic approaches are just as important as surgery.
基底样鳞状细胞癌是一种罕见的高恶性癌变体，通常位于舌根、声门上区和梨状窦。由于其倾向于黏膜下生长、深层浸润以及早期局部和远处转移，通常仅在非常晚期才被诊断出来。
患者/方法：所描述的病例为一名39岁男性，具有该肿瘤典型的临床和组织病理学表现。
与单纯鳞状细胞癌相比，预后极差的基底样变体需要做出特别考虑生活质量的治疗决策。应当强调的是，由于局部复发率高和早期远处转移，高度侵入性手术仅在特殊情况下才合理。
所呈现的病例表明，放疗和化疗方法与手术同样重要。
