疾病发病年龄影响帕金森病的认知功能。

Age of disease onset influences cognition in Parkinson's disease.

作者信息

Katzen H L, Levin B E, Llabre M L

机构信息

Department of Psychology, University of Miami, Coral Gables, FL, USA.

出版信息

J Int Neuropsychol Soc. 1998 May;4(3):285-90.

PMID:9623003

Abstract

It is controversial whether age of disease onset is related to cognitive decline in Parkinson's disease (PD). We administered 7 cognitive measures assessing visuospatial skills, memory, and executive functions to 222 patients with idiopathic PD and 108 normal control participants. Regression analyses demonstrated that older age of disease onset consistently predicted cognitive decline above and beyond normative aging and duration of illness. These findings suggest that older age of disease onset is a critical determinant of cognitive deterioration in PD.

摘要

帕金森病（PD）的发病年龄是否与认知衰退相关存在争议。我们对222例特发性PD患者和108名正常对照参与者进行了7项认知测试，以评估视觉空间技能、记忆和执行功能。回归分析表明，发病年龄较大始终预示着除正常衰老和病程之外的认知衰退。这些发现提示，发病年龄较大是PD认知恶化的一个关键决定因素。