Kuipers E J, Klinkenberg-Knol E C, Festen H P, Meuwissen S G
Academisch Ziekenhuis Vrije Universiteit, afd. Gastro-enterologie, Amsterdam.
Ned Tijdschr Geneeskd. 1998 Apr 18;142(16):883-5.
The pattern of Helicobacter pylori gastritis depends on acid secretion. Profound acid suppressive therapy with proton pump inhibitors leads to a decrease of antral gastritis, but an increased severity of corpus gastritis. As such, maintenance therapy with these drugs for gastroesophageal reflux disease has consistently been associated with an increased incidence of atrophic gastritis in H. pylori infected patients. For this reason, the preventive effect of H. pylori eradication in these patients needs to be considered; this is being studied in prospective trials.
幽门螺杆菌胃炎的模式取决于胃酸分泌。使用质子泵抑制剂进行深度抑酸治疗会导致胃窦炎减轻，但胃体炎的严重程度增加。因此，使用这些药物对胃食管反流病进行维持治疗一直与幽门螺杆菌感染患者萎缩性胃炎的发病率增加有关。出于这个原因，需要考虑在这些患者中根除幽门螺杆菌的预防作用；这正在前瞻性试验中进行研究。
