Harris S S, Hunt C E, Alvarez C J, Navia J M
J Oral Pathol. 1978 Apr;7(2):85-90. doi: 10.1111/j.1600-0714.1978.tb01582.x.
Using a standardized guinea pig model system, the histologic appearance of newly formed bone from vitamin A deficient, vitamin A adequate and retinoic acid treated animals was compared. Microscopic examination of the histologic sections of bone collected from vitamin A deficient guinea pigs indicated the presence of highly cellular and loosely woven bone spicules. This model system is an osteoblastic model, since osteoclasts are essentially absent in tissue formed in 14-day implants. Thus, new bone formation in the vitamin A deficient guinea pig reveals morphologic changes which are principally mediated through the osteoblastic process.
利用标准化的豚鼠模型系统，比较了维生素A缺乏、维生素A充足和经视黄酸处理的动物新形成骨的组织学外观。对从维生素A缺乏的豚鼠收集的骨组织切片进行显微镜检查，结果显示存在细胞高度密集且编织疏松的骨针。该模型系统是成骨细胞模型，因为在14天植入物形成的组织中基本不存在破骨细胞。因此，维生素A缺乏的豚鼠中的新骨形成揭示了主要通过成骨细胞过程介导的形态学变化。
