Greenstein G, Polson A
Department of Periodontology, University of Medicine and Dentistry, Newark, NJ, USA.
J Periodontol. 1998 May;69(5):507-20. doi: 10.1902/jop.1998.69.5.507.
This review article evaluates the role of local drug delivery systems in the management of periodontal diseases. The efficacy of several local delivery devices (i.e., tetracycline fibers, metronidazole and minocycline gels, chlorhexidine chips, and doxycycline polymer) which are either commercially available in the United States or abroad, or are currently under consideration for Food and Drug Administration (FDA) approval are discussed. The drug delivery systems are assessed with regard to their functional characteristics, effectiveness as a monotherapy, as compared to scaling and root planing, and ability to enhance conventional therapy. Furthermore, controversies associated with local delivery are addressed (e.g., induction of bacterial resistant strains, the efficacy of systemic versus local drug delivery, and whether local drug delivery should function as an alternative or as an adjunct to conventional treatment).
这篇综述文章评估了局部给药系统在牙周疾病治疗中的作用。讨论了几种在美国或国外已上市，或正在等待美国食品药品监督管理局（FDA）批准的局部给药装置（即四环素纤维、甲硝唑和米诺环素凝胶、洗必泰芯片和强力霉素聚合物）的疗效。对这些给药系统的功能特性、作为单一疗法与龈下刮治和根面平整相比的有效性以及增强传统治疗的能力进行了评估。此外，还讨论了与局部给药相关的争议（例如，诱导细菌耐药菌株、全身给药与局部给药的疗效，以及局部给药应作为传统治疗的替代方法还是辅助方法）。
