分泌型白细胞蛋白酶抑制剂：一种提供新治疗选择的天然抗菌蛋白？
Secretory leukoprotease inhibitor: a native antimicrobial protein presenting a new therapeutic option?
作者信息
Tomee J F, Koëter G H, Hiemstra P S, Kauffman H F
机构信息
Department of Pulmonology, University Hospital Groningen, The Netherlands.
出版信息
Thorax. 1998 Feb;53(2):114-6. doi: 10.1136/thx.53.2.114.
Abstract
Secretory leukoprotease inhibitor (SLPI) is a low molecular weight serine protease inhibitor found on various mucosal surfaces and has been ascribed an important role in maintaining the protease-anti-protease balance of the airways. Recent scientific evidence has suggested that SLPI may also have a broad spectrum antibiotic activity that includes antiretroviral, bactericidal, and antifungal activity. Given the unpropitious development of drug resistance to infectious micro-organisms in the human population, the need for therapeutic alternatives in the treatment of infectious diseases has become clear. SLPI may prove valuable in the prophylaxis and future treatment of infectious diseases, yet the clinical efficacy of SLPI remains largely to be elucidated.
摘要
分泌型白细胞蛋白酶抑制剂（SLPI）是一种在各种黏膜表面发现的低分子量丝氨酸蛋白酶抑制剂，在维持气道蛋白酶-抗蛋白酶平衡方面发挥着重要作用。最近的科学证据表明，SLPI可能还具有广谱抗菌活性，包括抗逆转录病毒、杀菌和抗真菌活性。鉴于人类群体中针对传染性微生物的耐药性发展不利，治疗传染病的替代疗法的需求已变得清晰。SLPI在传染病的预防和未来治疗中可能具有重要价值，但其临床疗效在很大程度上仍有待阐明。
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本文引用的文献
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J Infect Dis. 1997 Sep;176(3):740-7. doi: 10.1086/514098.
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Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines.烟曲霉的蛋白酶可诱导气道上皮细胞系释放促炎细胞因子并导致细胞脱离。
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Secretory leukoprotease inhibitor: partnering alpha 1-proteinase inhibitor to combat pulmonary inflammation.分泌型白细胞蛋白酶抑制剂：与α1-抗胰蛋白酶协同对抗肺部炎症。
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