Tomee J F, Koëter G H, Hiemstra P S, Kauffman H F
Department of Pulmonology, University Hospital Groningen, The Netherlands.
Thorax. 1998 Feb;53(2):114-6. doi: 10.1136/thx.53.2.114.
Secretory leukoprotease inhibitor (SLPI) is a low molecular weight serine protease inhibitor found on various mucosal surfaces and has been ascribed an important role in maintaining the protease-anti-protease balance of the airways. Recent scientific evidence has suggested that SLPI may also have a broad spectrum antibiotic activity that includes antiretroviral, bactericidal, and antifungal activity. Given the unpropitious development of drug resistance to infectious micro-organisms in the human population, the need for therapeutic alternatives in the treatment of infectious diseases has become clear. SLPI may prove valuable in the prophylaxis and future treatment of infectious diseases, yet the clinical efficacy of SLPI remains largely to be elucidated.
分泌型白细胞蛋白酶抑制剂（SLPI）是一种在各种黏膜表面发现的低分子量丝氨酸蛋白酶抑制剂，在维持气道蛋白酶-抗蛋白酶平衡方面发挥着重要作用。最近的科学证据表明，SLPI可能还具有广谱抗菌活性，包括抗逆转录病毒、杀菌和抗真菌活性。鉴于人类群体中针对传染性微生物的耐药性发展不利，治疗传染病的替代疗法的需求已变得清晰。SLPI在传染病的预防和未来治疗中可能具有重要价值，但其临床疗效在很大程度上仍有待阐明。
