分泌型白细胞蛋白酶抑制剂：与α1-抗胰蛋白酶协同对抗肺部炎症。
Secretory leukoprotease inhibitor: partnering alpha 1-proteinase inhibitor to combat pulmonary inflammation.
作者信息
Bingle L, Tetley T D
机构信息
Department of Medicine, Charing Cross and Westminster Medical School, London, UK.
出版信息
Thorax. 1996 Dec;51(12):1273-4. doi: 10.1136/thx.51.12.1273.
Abstract
Secretory leukoprotease inhibitor (SLPI) is a low molecular weight serine proteinase inhibitor, notably of neutrophil elastase (NE), which is synthesised and secreted by the pulmonary epithelium. SLPI plays an important role in limiting NE-induced pulmonary inflammation and, significantly, it also possesses anti-HIV activity. SLPI is a significant component of the anti-NE shield in the lung which has different reactivity from, and is therefore complementary to, the anti-NE action of alpha 1-proteinase inhibitor (alpha 1-PI). Inhaled recombinant SLPI (rSLPI) could prove beneficial in partnership with alpha 1-PI in the treatment of a number of inflammatory lung disorders including emphysema, chronic bronchitis, cystic fibrosis, and adult respiratory distress syndrome.
摘要
分泌型白细胞蛋白酶抑制剂（SLPI）是一种低分子量丝氨酸蛋白酶抑制剂，尤其对中性粒细胞弹性蛋白酶（NE）有抑制作用，它由肺上皮细胞合成并分泌。SLPI在限制NE诱导的肺部炎症方面发挥重要作用，并且值得注意的是，它还具有抗HIV活性。SLPI是肺部抗NE屏障的重要组成部分，其反应性与α1-蛋白酶抑制剂（α1-PI）的抗NE作用不同，因此二者具有互补性。吸入重组SLPI（rSLPI）与α1-PI联合使用，可能对治疗包括肺气肿、慢性支气管炎、囊性纤维化和成人呼吸窘迫综合征在内的多种炎症性肺部疾病有益。
相似文献
1
Secretory leukoprotease inhibitor: partnering alpha 1-proteinase inhibitor to combat pulmonary inflammation.分泌型白细胞蛋白酶抑制剂：与α1-抗胰蛋白酶协同对抗肺部炎症。
Thorax. 1996 Dec;51(12):1273-4. doi: 10.1136/thx.51.12.1273.
2
Use of secretory leukoprotease inhibitor to augment lung antineutrophil elastase activity.使用分泌型白细胞蛋白酶抑制剂增强肺抗中性粒细胞弹性蛋白酶活性。
Chest. 1996 Dec;110(6 Suppl):261S-266S. doi: 10.1378/chest.110.6_supplement.261s.
3
Anti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor.分泌型白细胞蛋白酶抑制剂对正常人呼吸道上皮表面的抗中性粒细胞弹性蛋白酶防御作用。
J Clin Invest. 1991 Feb;87(2):482-8. doi: 10.1172/JCI115021.
4
Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium.雾化重组分泌性白细胞蛋白酶抑制因子以增强对肺上皮细胞的抗中性粒细胞弹性蛋白酶保护作用。
J Appl Physiol (1985). 1990 Nov;69(5):1843-8. doi: 10.1152/jappl.1990.69.5.1843.
5
Effects of native and oxidation-resistant secretory leukoprotease inhibitor on cystic fibrosis sputum: inhibition of neutrophil elastase activity and of sputum-induced secretion from porcine tracheal submucosal glands.天然及抗氧化分泌型白细胞蛋白酶抑制剂对囊性纤维化痰液的影响：对中性粒细胞弹性蛋白酶活性及猪气管黏膜下腺痰液诱导分泌的抑制作用
Pediatr Res. 1996 Nov;40(5):732-7. doi: 10.1203/00006450-199611000-00013.
6
Comparative loss of activity of recombinant secretory leukoprotease inhibitor and alpha 1-protease inhibitor caused by different forms of oxidative stress.不同形式氧化应激导致重组分泌型白细胞蛋白酶抑制剂和α1-蛋白酶抑制剂活性的比较性丧失。
Eur Respir J. 1997 Sep;10(9):2114-9. doi: 10.1183/09031936.97.10092114.
7
Intravenous recombinant secretory leukoprotease inhibitor augments antineutrophil elastase defense.静脉注射重组分泌型白细胞蛋白酶抑制剂可增强抗中性粒细胞弹性蛋白酶防御功能。
J Appl Physiol (1985). 1992 Jul;73(1):317-23. doi: 10.1152/jappl.1992.73.1.317.
8
Recombinant secretory leukoprotease inhibitor augments glutathione levels in lung epithelial lining fluid.重组分泌型白细胞蛋白酶抑制剂可提高肺上皮衬液中的谷胱甘肽水平。
J Appl Physiol (1985). 1993 Aug;75(2):825-32. doi: 10.1152/jappl.1993.75.2.825.
9
Protease-antiprotease imbalance in the lungs of children with cystic fibrosis.囊性纤维化患儿肺部的蛋白酶-抗蛋白酶失衡
Am J Respir Crit Care Med. 1994 Jul;150(1):207-13. doi: 10.1164/ajrccm.150.1.7912987.
10
[Therapy of lung diseases with antiproteases].[用抗蛋白酶治疗肺部疾病]
Pneumologie. 1994 Feb;48(2):57-62.
引用本文的文献
1
Role of Cystic Fibrosis Bronchial Epithelium in Neutrophil Chemotaxis.囊性纤维化支气管上皮细胞在中性粒细胞趋化中的作用。
Front Immunol. 2020 Aug 4;11:1438. doi: 10.3389/fimmu.2020.01438. eCollection 2020.
2
The Role of Nrf2 in Cellular Innate Immune Response to Inflammatory Injury.Nrf2在细胞对炎症损伤的固有免疫反应中的作用
Toxicol Res. 2009 Dec;25(4):159-173. doi: 10.5487/TR.2009.25.4.159. Epub 2009 Dec 30.
3
A comparative proteomic analysis of the soluble immune factor environment of rectal and oral mucosa.直肠和口腔黏膜可溶性免疫因子环境的比较蛋白质组学分析
PLoS One. 2014 Jun 30;9(6):e100820. doi: 10.1371/journal.pone.0100820. eCollection 2014.
4
Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model.多能基质细胞的旁分泌因子可改善弹性蛋白酶诱导的肺气肿模型中的肺损伤。
Mol Ther. 2011 Jan;19(1):196-203. doi: 10.1038/mt.2010.192. Epub 2010 Sep 14.
5
Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis.Nrf2-Keap1 信号通路作为炎症相关癌变化学预防的潜在靶点。
Pharm Res. 2010 Jun;27(6):999-1013. doi: 10.1007/s11095-010-0096-8. Epub 2010 Mar 31.
6
Susceptibility of lung epithelium to neutrophil elastase: protection by native inhibitors.肺上皮细胞对中性粒细胞弹性蛋白酶的易感性：天然抑制剂的保护作用。
Mediators Inflamm. 1997;6(5-6):345-54. doi: 10.1080/09629359791488.
7
Increased expression of the secretory leukocyte proteinase inhibitor in Wegener's granulomatosis.韦格纳肉芽肿中分泌型白细胞蛋白酶抑制剂表达增加。
Clin Exp Immunol. 2003 Jan;131(1):190-6. doi: 10.1046/j.1365-2249.2003.02024.x.
8
The protease-antiprotease battle in the cystic fibrosis lung.囊性纤维化肺部的蛋白酶-抗蛋白酶之战
J R Soc Med. 1999;92 Suppl 37(Suppl 37):23-30. doi: 10.1177/014107689909237S05.
9
Injury to murine airway epithelial cells by pollen enzymes.花粉酶对小鼠气道上皮细胞的损伤。
Thorax. 1998 May;53(5):368-71. doi: 10.1136/thx.53.5.368.
10
New ideas on the pathophysiology and treatment of lung disease.关于肺部疾病病理生理学及治疗的新观点。
Thorax. 1998 Mar;53(3):200-3. doi: 10.1136/thx.53.3.200.
本文引用的文献
1
Pharmacokinetics of recombinant secretory leukoprotease inhibitor aerosolized to normals and individuals with cystic fibrosis.重组分泌型白细胞蛋白酶抑制剂雾化吸入正常人和囊性纤维化患者后的药代动力学
Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):1056-60. doi: 10.1164/ajrccm/148.4_Pt_1.1056.
2
Neutrophil elastase increases secretory leukocyte protease inhibitor transcript levels in airway epithelial cells.中性粒细胞弹性蛋白酶可提高气道上皮细胞中分泌性白细胞蛋白酶抑制剂的转录水平。
Am J Physiol. 1993 Sep;265(3 Pt 1):L286-92. doi: 10.1152/ajplung.1993.265.3.L286.
3
Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes.细胞因子和中性粒细胞酶对人气道上皮细胞中分泌型白细胞蛋白酶抑制剂（SLPI）和弹性蛋白酶特异性抑制剂（ESI/elafin）的调节作用
Am J Respir Cell Mol Biol. 1994 Dec;11(6):733-41. doi: 10.1165/ajrcmb.11.6.7946401.
4
Oxidized mucus proteinase inhibitor: a fairly potent neutrophil elastase inhibitor.氧化型黏液蛋白酶抑制剂：一种相当有效的中性粒细胞弹性蛋白酶抑制剂。
Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):61-8. doi: 10.1042/bj3030061.
5
Recombinant secretory leukoprotease inhibitor augments glutathione levels in lung epithelial lining fluid.重组分泌型白细胞蛋白酶抑制剂可提高肺上皮衬液中的谷胱甘肽水平。
J Appl Physiol (1985). 1993 Aug;75(2):825-32. doi: 10.1152/jappl.1993.75.2.825.
6
Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor.
Thorax. 1995 Jun;50(6):645-50. doi: 10.1136/thx.50.6.645.
7
Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro.分泌型白细胞蛋白酶抑制剂：一种在体外具有抗人免疫缺陷病毒1活性的人唾液蛋白。
J Clin Invest. 1995 Jul;96(1):456-64. doi: 10.1172/JCI118056.
8
Kinetics of the inhibition of leukocyte elastase by the bronchial inhibitor.支气管抑制剂对白细胞弹性蛋白酶的抑制动力学
Biochim Biophys Acta. 1982 Jan 18;700(2):178-83. doi: 10.1016/0167-4838(82)90095-4.
9
Effects of cigarette smoking and drugs on respiratory tract proteases and antiproteases.吸烟和药物对呼吸道蛋白酶及抗蛋白酶的影响。
Eur J Respir Dis Suppl. 1987;153:93-102.
10
Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium.雾化重组分泌性白细胞蛋白酶抑制因子以增强对肺上皮细胞的抗中性粒细胞弹性蛋白酶保护作用。
J Appl Physiol (1985). 1990 Nov;69(5):1843-8. doi: 10.1152/jappl.1990.69.5.1843.
Zotero 插件