Chand N, Eyre P
Arch Int Pharmacodyn Ther. 1976 Jun;221(2):261-65.
The predominant effect of PGE1, E2, and F2 alpha on systemic arterial pressure of domestic fowl is hypotension. PGE1 and E2 are approximately equiactive and PGF2 alpha is about 10 times less active than E1 and E2, PGE1 and E2 produce sudden hypotension with gradual recovery while F2 alpha produces fall in blood pressure with both slow onset and recovery. Polyphloretin phosphate itself produces depressor responses in chickens and antagonizes the depressor responses to the prostaglandins dose-dependently.
前列腺素E1、E2和F2α对家禽体循环动脉血压的主要作用是引起低血压。前列腺素E1和E2的活性大致相当，而前列腺素F2α的活性约比E1和E2低10倍。前列腺素E1和E2可导致血压突然下降并逐渐恢复，而前列腺素F2α则使血压下降，其起效和恢复均较慢。聚磷酸根皮苷本身可使鸡产生降压反应，并能剂量依赖性地拮抗前列腺素引起的降压反应。
