Effects of prostaglandins E1, E2 and F2 alpha and polyphloretin phosphate of domestic fowl.

The predominant effect of PGE1, E2, and F2 alpha on systemic arterial pressure of domestic fowl is hypotension. PGE1 and E2 are approximately equiactive and PGF2 alpha is about 10 times less active than E1 and E2, PGE1 and E2 produce sudden hypotension with gradual recovery while F2 alpha produces fall in blood pressure with both slow onset and recovery. Polyphloretin phosphate itself produces depressor responses in chickens and antagonizes the depressor responses to the prostaglandins dose-dependently.